Product Name
AICDA (Activation-induced cytidine deaminase), Polyclonal Antibody
Full Product Name
Anti-AICDA (Activation-induced cytidine deaminase) Antibody
Product Gene Name
anti-AICDA antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Purified by antigen-specific affinity chromatography.
Concentration
1ug/ul (lot specific)
Immunogen
Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of mouse AICDA (Activation-induced cytidine deaminase)
Storage Buffer
PBS, pH 7.4 with 0.05% sodium azide.
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Other Notes
Small volumes of anti-AICDA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AICDA antibody
The AICDA (Activation-induced cytidine deaminase)is a RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. It is required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. It belongs to the cytidine and deoxycytidylate deaminases family.
Applications Tested/Suitable for anti-AICDA antibody
Western Blot (WB), ELISA (EIA)
NCBI/Uniprot data below describe general gene information for AICDA. It may not necessarily be applicable to this product.
NCBI Accession #
BAB12721.1
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UniProt Secondary Accession #
Q6QJ81; Q8NFC1[Other Products]
UniProt Related Accession #
Q9GZX7[Other Products]
Molecular Weight
22,614 Da
NCBI Official Full Name
activation-induced cytidine deaminase
NCBI Official Synonym Full Names
activation induced cytidine deaminase
NCBI Official Symbol
AICDA [Similar Products]
NCBI Official Synonym Symbols
AID; ARP2; CDA2; HIGM2; HEL-S-284
[Similar Products]
NCBI Protein Information
single-stranded DNA cytosine deaminase
UniProt Protein Name
Single-stranded DNA cytosine deaminase
UniProt Synonym Protein Names
Activation-induced cytidine deaminase; AID; Cytidine aminohydrolase
Protein Family
Single-stranded DNA cytosine deaminase
UniProt Gene Name
AICDA [Similar Products]
UniProt Synonym Gene Names
AID; AID [Similar Products]
NCBI Summary for AICDA
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]
UniProt Comments for AICDA
AID: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family.
Protein type: EC 3.5.4.38; Hydrolase
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: cytoplasm; exosome (RNase complex); nucleus
Molecular Function: cytidine deaminase activity; protein binding; ubiquitin protein ligase binding
Biological Process: somatic diversification of immunoglobulins; somatic hypermutation of immunoglobulin genes
Disease: Immunodeficiency With Hyper-igm, Type 2
Product References and Citations for anti-AICDA antibody
Muramatsu, M., et al, J. Biol. Chem. 274 McBride, K.M., et al, Proc. Natl. Acad. Sci. U.S.A. 103 (23), 8798-8803 (2006) Ramiro, A.R., et al, Nature 440 (7080), 105-109 (2006) Muto, T., et al, Proc. Natl. Acad. Sci. U.S.A. 103 (8), 2752-2757 (2006) Yadav, A., et al, Mol. Immunol. 43 (6),529-541 (2006) Krause, K., et al, Mol. Immunol. 43 (4), 295-307 (2006) Wakae, K., et al, Int. Immunol. 18 (1), 41-47 (2006) Basu, U., et al, Nature 438 (7067),508-511 (2005) Cattoretti, G., et al, Cancer Cell 7 (5), 445-455 (2005)
Research Articles on AICDA
1. this study reports a case of growth hormone deficiency with an autosomal recessive Hyper-immunoglobulin M syndrome by phenotype and genotype, with a novel mutation in AICDA that has not been reported formerly
Precautions
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Disclaimer
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