Product Name
Arsenic Methyltransferase (AS3MT), Recombinant Protein
Full Product Name
Recombinant Human Arsenic Methyltransferase
Product Synonym Names
AS3MT Human; Arsenic Methyltransferase Human Recombinant; Arsenite methyltransferase; Methylarsonite methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase; AS3MT; CYT19; RP11-753C18.6
Product Gene Name
AS3MT recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHH HHH SSGLVPRGSH MGSHMA ALRD AEIQKDVQTY YGQVLKRSAD LQTNGCVTTA RPVPKHIREA LQNVHEEVAL RYYGCGLVIP EHLENCWILD LGSGSGRDCY VLSQLVGEKG HVTGIDMTKG QVEVAEKYLD YHMEKYGFQA SNVTFIHGYI EKLGEAGIKN ESHDIVVSNC VINLVPDKQQ VLQEAYRVLK HGGELYFSDV YTSLELPEEI RTHKVLWGEC LGGALYWKEL AVLAQKIGFC PPRLVTANLI TIQNKELERV IGDCRFVSAT FRLFKHSKTG PTKRCQVIYN GGITGHEKEL MFDANFTFKE GEIVEVDEET AAILKNSRFA QDFLIRPIGE KLPTSGGCSA LELKDIITDP FKLAEESDSM KSRCVPDAAG GCCGTKKSC.
3D Structure
ModBase 3D Structure for Q9HBK9
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Form/Format
AS3MT protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.15M NaCl.
Sterile Filtered colorless solution.
Other Notes
Small volumes of AS3MT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
AS3MT recombinant protein
Description: AS3MT Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 399 amino acids (1-375 a.a.) and having a molecular mass of 44.3kDa.AS3MT is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction: Arsenic Methyltransferase (AS3MT) catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may have a role in arsenic metabolism. AS3MT methylates arsenite to produce methylarsonate, Me-AsO3H2, which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite which is also a substrate, is transformed into the much less toxic complex dimethylarsinate (cacodylate), Me2As(O)-OH.
Product Categories/Family for AS3MT recombinant protein
ENZYMES; Enzymes; Transferase
NCBI/Uniprot data below describe general gene information for AS3MT. It may not necessarily be applicable to this product.
NCBI Accession #
NP_065733.2
[Other Products]
NCBI GenBank Nucleotide #
NM_020682.3
[Other Products]
UniProt Primary Accession #
Q9HBK9
[Other Products]
UniProt Secondary Accession #
Q0VDK3; Q0VDK4; Q5PZ02; A6NP79[Other Products]
UniProt Related Accession #
Q9HBK9[Other Products]
Molecular Weight
31,098 Da
NCBI Official Full Name
arsenite methyltransferase
NCBI Official Synonym Full Names
arsenite methyltransferase
NCBI Official Symbol
AS3MT [Similar Products]
NCBI Official Synonym Symbols
CYT19
[Similar Products]
NCBI Protein Information
arsenite methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase; S-adenosylmethionine:arsenic (III) methyltransferase; arsenic (+3 oxidation state) methyltransferase; methylarsonite methyltransferase; methyltransferase cyt19
UniProt Protein Name
Arsenite methyltransferase
UniProt Synonym Protein Names
Methylarsonite methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase
Protein Family
Arsenite methyltransferase
UniProt Gene Name
AS3MT [Similar Products]
UniProt Synonym Gene Names
CYT19 [Similar Products]
UniProt Entry Name
AS3MT_HUMAN
NCBI Summary for AS3MT
AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]
UniProt Comments for AS3MT
AS3MT: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. Belongs to the methyltransferase superfamily.
Protein type: Methyltransferase; Mitochondrial; EC 2.1.1.137
Chromosomal Location of Human Ortholog: 10q24.32
Cellular Component: mitochondrion; cytoplasm; cytosol
Molecular Function: arsenite methyltransferase activity; methylarsonite methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity
Biological Process: methylation; arsonoacetate metabolic process; toxin metabolic process
Research Articles on AS3MT
1. Two SNPs, AS3MT 12390 (rs3740393) and 14458 (rs11191439) were consistently related to arsenic methylation regardless of the populations examined for the analysis.
Precautions
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Disclaimer
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