T-Box Protein 3 (TBX3), Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

The antibody is a rabbit polyclonal antibody raised against TBX3. It has been selected for its ability to recognize TBX3 in immunohistochemical staining andwestern blotting.

Affinity Chromatography

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.

200ug/ml (lot specific)

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of anti-TBX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot: Sample: Recombinant TBX3, Mouse.

DABstainingonIHC-P.Samples:MouseTissue)

76,949 Da

T-box 3

T-box transcription factor TBX3

T-box transcription factor TBX3

T-box protein 3  [Similar Products]

TBX3: Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS). UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 5 F|5 60.34 cM

Cellular Component: nucleus; transcription factor complex

Molecular Function: DNA binding; DNA binding transcription factor activity; sequence-specific DNA binding

Biological Process: anterior/posterior axis specification, embryo; atrioventricular bundle cell differentiation; blood vessel development; cardiac muscle cell differentiation; cell aging; cellular senescence; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic heart tube development; embryonic hindlimb morphogenesis; female genitalia development; follicle-stimulating hormone secretion; forelimb morphogenesis; heart looping; heart morphogenesis; in utero embryonic development; limb morphogenesis; limbic system development; luteinizing hormone secretion; male genitalia development; mammary gland development; mesoderm morphogenesis; multicellular organism development; negative regulation of apoptosis; negative regulation of epithelial cell differentiation; negative regulation of myoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; organ morphogenesis; outflow tract morphogenesis; palate development; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of stem cell proliferation; positive regulation of transcription, DNA-templated; regulation of cell proliferation; regulation of transcription, DNA-templated; skeletal system development; specification of organ position; stem cell maintenance; transcription, DNA-dependent

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