Product Name
Hyaluronan synthase 3 (HAS3), Recombinant Protein
Full Product Name
Recombinant Human Hyaluronan synthase 3 (HAS3)
Product Gene Name
HAS3 recombinant protein
[Similar Products]
Product Synonym Gene Name
Recombinant Hyaluronan synthase 3 (HAS3); Hyaluronan synthase 3 EC= 2.4.1.212; Hyaluronate synthase 3 Hyaluronic acid synthase 3; HA synthase 3[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MPVQLTTALR VVGTSLFALA VLGGILAAYV TGYQFIHTEK HYLSFGLYGA ILGLHLLIQS LFAFLEHRRM RRAGQALKLP SPRRGSVALC IAAYQEDPDY LRKCLRSAQR ISFPDLKVVM VVDGNRQEDA YMLDIFHEVL GGTEQAGFFV WRSNFHEAGE GETEASLQEG MDRVRDVVRA STFSCIMQKW GGKREVMYTA FKALGDSVDY IQVCDSDTVL DPACTIEMLR VLEEDPQVGG VGGDVQILNK YDSWISFLSS VRYWMAFNVE RACQSYFGCV QCISGPLGMY RNSLLQQFLE DWYHQKFLGS KCSFGDDRHL TNRVLSLGYR TKYTARSKCL TETPTKYLRW LNQQTRWSKS YFREWLYNSL WFHKHHLWMT YESVVTGFFP FFLIATVIQL FYRGRIWNIL LFLLTVQLVG IIKATYACFL RGNAEMIFMS LYSLLYMSSL LPAKIFAIAT INKSGWGTSG RKTIVVNFIG LIPVSIWVAV LLGGLAYTAY CQDLFSETEL AFLVSGAILY GCYWVALLML YLAIIARRCG KKPEQYSLAF AEV
Chromosome Location
Chromosome: 16; NC_000016.9 (69139467..69152622). Location: 16q22.1
3D Structure
ModBase 3D Structure for O00219
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of HAS3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
HAS3 recombinant protein
HAS3
NCBI/Uniprot data below describe general gene information for HAS3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001186209.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001199280.1
[Other Products]
UniProt Primary Accession #
O00219
[Other Products]
UniProt Secondary Accession #
Q8WTZ0; Q9NYP0; A8K5T5[Other Products]
UniProt Related Accession #
O00219[Other Products]
Molecular Weight
62,998 Da[Similar Products]
NCBI Official Full Name
hyaluronan synthase 3 isoform a
NCBI Official Synonym Full Names
hyaluronan synthase 3
NCBI Official Symbol
HAS3 [Similar Products]
NCBI Protein Information
hyaluronan synthase 3; HA synthase 3; hyaluronate synthase 3; hyaluronic acid synthase 3
UniProt Protein Name
Hyaluronan synthase 3
UniProt Synonym Protein Names
Hyaluronate synthase 3; Hyaluronic acid synthase 3
Protein Family
Hyaluronan synthase
UniProt Gene Name
HAS3 [Similar Products]
UniProt Synonym Gene Names
HA synthase 3 [Similar Products]
UniProt Entry Name
HAS3_HUMAN
NCBI Summary for HAS3
The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
UniProt Comments for HAS3
HAS3: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Belongs to the NodC/HAS family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; EC 2.4.1.212; Transferase
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane
Molecular Function: hyaluronan synthase activity
Biological Process: glycosaminoglycan metabolic process; extracellular polysaccharide biosynthetic process; hyaluronan biosynthetic process; positive regulation of transcription, DNA-dependent; carbohydrate metabolic process; pathogenesis; cell adhesion; hyaluronan metabolic process
Research Articles on HAS3
1. HA chains synthesized by HAS1 and HAS2 contribute to outflow resistance, while hyaluronan produced by HAS3 does not appear to play a significant role.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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