Product Name
Long-chain fatty acid transport protein 4 (Slc27a4), Recombinant Protein
Full Product Name
Recombinant Mouse Long-chain fatty acid transport protein 4 (Slc27a4)
Product Gene Name
Slc27a4 recombinant protein
[Similar Products]
Product Synonym Gene Name
Acsvl4; Fatp4[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-643aa; full length protein
Sequence
MLLGASLVGA LLFSKLVLKL PWTQVGFSLL LLYLGSGGWR FIRVFIKTVR RDIFGGMVLL KVKTKVRRYL QERKTVPLLF ASMVQRHPDK TALIFEGTDT HWTFRQLDEY SSSVANFLQA RGLASGNVVA LFMENRNEFV GLWLGMAKLG VEAALINTNL RRDALRHCLD TSKARALIFG SEMASAICEI HASLEPTLSL FCSGSWEPST VPVSTEHLDP LLEDAPKHLP SHPDKGFTDK LFYIYTSGTT GLPKAAIVVH SRYYRMASLV YYGFRMRPDD IVYDCLPLYH SAGNIVGIGQ CLLHGMTVVI RKKFSASRFW DDCIKYNCTI VQYIGELCRY LLNQPPREAE SRHKVRMALG NGLRQSIWTD FSSRFHIPQV AEFYGATECN CSLGNFDSRV GACGFNSRIL SFVYPIRLVR VNEDTMELIR GPDGVCIPCQ PGQPGQLVGR IIQQDPLRRF DGYLNQGANN KKIANDVFKK GDQAYLTGDV LVMDELGYLY FRDRTGDTFR WKGENVSTTE VEGTLSRLLH MADVAVYGVE VPGTEGRAGM AAVASPISNC DLESFAQTLK KELPLYARPI FLRFLPELHK TGTFKFQKTE LRKEGFDPSV VKDPLFYLDA RKGCYVALDQ EAYTRIQAGE EKL
3D Structure
ModBase 3D Structure for Q91VE0
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Slc27a4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Slc27a4 recombinant protein
Transmembrane Protein
Application Notes for Slc27a4 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for Slc27a4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_036119.1
[Other Products]
NCBI GenBank Nucleotide #
NM_011989.4
[Other Products]
UniProt Primary Accession #
Q91VE0
[Other Products]
UniProt Secondary Accession #
O88562; Q3TD48[Other Products]
UniProt Related Accession #
Q91VE0[Other Products]
Molecular Weight
72,319 Da
NCBI Official Full Name
long-chain fatty acid transport protein 4
NCBI Official Synonym Full Names
solute carrier family 27 (fatty acid transporter), member 4
NCBI Official Symbol
Slc27a4 [Similar Products]
NCBI Official Synonym Symbols
FATP4; BB144259
[Similar Products]
NCBI Protein Information
long-chain fatty acid transport protein 4
UniProt Protein Name
Long-chain fatty acid transport protein 4
UniProt Synonym Protein Names
Solute carrier family 27 member 4
Protein Family
Long-chain fatty acid transport protein
UniProt Gene Name
Slc27a4 [Similar Products]
UniProt Synonym Gene Names
Acsvl4; Fatp4; FATP-4; Fatty acid transport protein 4 [Similar Products]
UniProt Entry Name
S27A4_MOUSE
UniProt Comments for Slc27a4
SLC27A4: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Defects in SLC27A4 are the cause of ichthyosis prematurity syndrome (IPS). A keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations. Belongs to the ATP-dependent AMP-binding enzyme family.
Protein type: Transporter; EC 6.2.1.-; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family; Ligase
Cellular Component: brush border membrane; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; membrane; microvillus; plasma membrane
Molecular Function: 2,4-dichlorobenzoate-CoA ligase activity; 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity; 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity; 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0) CoA ligase activity; acyl-CoA ligase activity; aryl-CoA synthetase (ADP-forming) activity; benzoyl acetate-CoA ligase activity; branched-chain acyl-CoA synthetase (ADP-forming) activity; catalytic activity; fatty-acid ligase activity; ligase activity; long-chain-fatty-acid-CoA ligase activity; nucleotide binding; succinate-CoA ligase activity; very-long-chain-fatty-acid-CoA ligase activity
Biological Process: fatty acid metabolic process; fatty acid transport; lipid metabolic process; lipid transport; long-chain fatty acid metabolic process; long-chain fatty acid transport; medium-chain fatty acid transport; metabolic process; skin development; transport; very-long-chain fatty acid catabolic process; very-long-chain fatty acid metabolic process
Research Articles on Slc27a4
1. Transgenic expression of FATP1 in suprabasal keratinocytes rescued the phenotype of Fatp4 mutants, and FATP1 sorted to the same intracellular organelles as endogenous FATP4
Precautions
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Disclaimer
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