Product Name
Cyt19 / AS3MT, Blocking Peptide
Full Product Name
Cyt19 / AS3MT Immunizing Peptide
Product Synonym Names
AS3MT; CYT19; Cyt19; Cyt19 protein; likely ortholog of rat methyltransferase Cyt19; S-adenosylmethionine: arsenic (III) methyltransferase; arsenic (+3 oxidation state) methyltransferase; RP11-753C18. 6; 2310045H08Rik; methylarsonite methyltransferase; methy; Cyt19 / AS3MT
Product Gene Name
AS3MT blocking peptide
[Similar Products]
Product Synonym Gene Name
Cyt19[Similar Products]
Cyt19 / AS3MT peptide (MBS425230) is used for blocking the activity of Cyt19/AS3MT antibody (MBS420776)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
AALRDAEIQK DVQ-C
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of AS3MT blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for AS3MT. It may not necessarily be applicable to this product.
NCBI Accession #
NP_065733.2
[Other Products]
NCBI GenBank Nucleotide #
NM_020682.3
[Other Products]
UniProt Secondary Accession #
Q0VDK3; Q0VDK4; Q5PZ02; A6NP79[Other Products]
UniProt Related Accession #
Q9HBK9[Other Products]
Molecular Weight
31,098 Da
NCBI Official Full Name
arsenite methyltransferase
NCBI Official Synonym Full Names
arsenite methyltransferase
NCBI Official Symbol
AS3MT [Similar Products]
NCBI Official Synonym Symbols
CYT19
[Similar Products]
NCBI Protein Information
arsenite methyltransferase
UniProt Protein Name
Arsenite methyltransferase
UniProt Synonym Protein Names
Methylarsonite methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase
Protein Family
Arsenite methyltransferase
UniProt Gene Name
AS3MT [Similar Products]
UniProt Synonym Gene Names
CYT19 [Similar Products]
UniProt Entry Name
AS3MT_HUMAN
NCBI Summary for AS3MT
AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]
UniProt Comments for AS3MT
AS3MT: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. Belongs to the methyltransferase superfamily.
Protein type: Methyltransferase; Mitochondrial; EC 2.1.1.137
Chromosomal Location of Human Ortholog: 10q24.32
Cellular Component: cytoplasm; cytosol; mitochondrion
Molecular Function: arsenite methyltransferase activity; methylarsonite methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity
Biological Process: arsonoacetate metabolic process; methylation; toxin metabolic process
Research Articles on AS3MT
1. The present study found that rs3740400 in As3MT and rs156697 in GSTO2 were strongly associated with the arsenic species (%iAs, %MMA and MMA/iAs and DMA/MMA ratios) in urine of the occupationally exposed workers and they may influence methylation capacity.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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