Product Name
ACTB, Blocking Peptide
Full Product Name
ACTB Peptide - N-terminal region
Product Gene Name
ACTB blocking peptide
[Similar Products]
Product Synonym Gene Name
BRWS1; PS1TP5BP1; ACTB[Similar Products]
ACTB peptide (MBS3246510) is used for blocking the activity of ACTB antibody (MBS3221784)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Synthetic peptide located within the following region: EEEIAALVID NGSGMCKAGF AGDDAPRAVF PSIVGRPRHQ GVMVGMGQKD
3D Structure
ModBase 3D Structure for P63261
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of ACTB blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ACTB blocking peptide
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome.
Product Categories/Family for ACTB blocking peptide
Peptide
NCBI/Uniprot data below describe general gene information for ACTB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001186883.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001199954.1
[Other Products]
UniProt Primary Accession #
P63261
[Other Products]
UniProt Related Accession #
P63261[Other Products]
NCBI Official Full Name
actin, cytoplasmic 2
NCBI Official Synonym Full Names
actin gamma 1
NCBI Official Symbol
ACTG1 [Similar Products]
NCBI Official Synonym Symbols
ACT; ACTG; DFNA20; DFNA26; HEL-176
[Similar Products]
NCBI Protein Information
actin, cytoplasmic 2
UniProt Protein Name
Actin, cytoplasmic 2
UniProt Synonym Protein Names
Gamma-actinActin, cytoplasmic 2, N-terminally processed
UniProt Gene Name
ACTG1 [Similar Products]
UniProt Synonym Gene Names
ACTG [Similar Products]
UniProt Entry Name
ACTG_HUMAN
NCBI Summary for ACTB
Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Actin gamma 1, encoded by this gene, is a cytoplasmic actin found in all cell types. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss and also with Baraitser-Winter syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
UniProt Comments for ACTB
ACTG1: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Belongs to the actin family.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 17q25
Cellular Component: filamentous actin; extracellular space; cytoskeleton; myofibril; membrane; plasma membrane; nucleus; cytosol
Molecular Function: identical protein binding; protein binding; structural constituent of cytoskeleton; ubiquitin protein ligase binding; ATP binding
Biological Process: axon guidance; retinal homeostasis; intercellular junction assembly and maintenance; ephrin receptor signaling pathway; innate immune response; sarcomere organization; cell motility; vascular endothelial growth factor receptor signaling pathway
Disease: Baraitser-winter Syndrome 2; Deafness, Autosomal Dominant 20
Research Articles on ACTB
1. A novel actin gamma 1 (ACTG1) de novo mutation is identified in two sporadic, juvenile, Chinese non-syndromic hearing loss (NSHL) cases using targeted high-throughput sequencing.
Precautions
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