Product Name
SLC27A4, cDNA Clone
Full Product Name
SLC27A4 cDNA Clone
Product Gene Name
SLC27A4 cdna clone
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgcccctca cgctgtctac gctgctgcaa ccgggccgca tctggacggg gcgccgcgcg gcggagccga cgccgggcca caatgctgct tggagcctct ctggtggggg tgctgctgtt ctccaagctg gtgctgaaac tgccctggac ccaggtggga ttctccctgt tgttcctcta cttgggatct ggcggctggc gcttcatccg ggtcttcatc aagaccatca ggcctacctt actggtgatg tgctggtgat ggacgagctg ggctacctgt acttccgaga ccgcactggg gacacgttcc gctggaaagg tgagaacgtg tccaccaccg aggtggaagg cacactcagc cgcctgctgg acatggctga cgtggccgtg tatggtgtcg aggtgccagg aaccgagggc cgggccggaa tggctgctgt ggccagcccc actggcaact gtgacctgga gcgctttgct caggtcttgg agaaggaact gcccctgtat gcgcgcccca tcttcctgcg cctcctgcct gagctgcaca aaacaggaac ctacaagttc cagaagacag agctacggaa ggagggcttt gacccggcta ttgtgaaaga cccgctgttc tatctagatg cccagaaggg ccgctacgtc ccgctggacc aagaggccta cagccgcatc caggcaggcg aggagaagct gtga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SLC27A4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SLC27A4. It may not necessarily be applicable to this product.
NCBI Accession #
BC009959
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UniProt Secondary Accession #
O95186; Q96G53; A8K2F7[Other Products]
UniProt Related Accession #
Q6P1M0[Other Products]
Molecular Weight
26,001 Da
NCBI Official Full Name
Homo sapiens solute carrier family 27 (fatty acid transporter), member 4, mRNA
NCBI Official Synonym Full Names
solute carrier family 27 member 4
NCBI Official Symbol
SLC27A4 [Similar Products]
NCBI Official Synonym Symbols
IPS; FATP4; ACSVL4
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NCBI Protein Information
long-chain fatty acid transport protein 4
UniProt Protein Name
Long-chain fatty acid transport protein 4
UniProt Synonym Protein Names
Solute carrier family 27 member 4
Protein Family
Long-chain fatty acid transport protein
UniProt Gene Name
SLC27A4 [Similar Products]
UniProt Synonym Gene Names
ACSVL4; FATP4; FATP-4; Fatty acid transport protein 4 [Similar Products]
UniProt Entry Name
S27A4_HUMAN
NCBI Summary for SLC27A4
This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010]
UniProt Comments for SLC27A4
SLC27A4: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Defects in SLC27A4 are the cause of ichthyosis prematurity syndrome (IPS). A keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations. Belongs to the ATP-dependent AMP-binding enzyme family.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; EC 6.2.1.-; Membrane protein, integral; Ligase; Transporter
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component: endoplasmic reticulum membrane; membrane; plasma membrane
Molecular Function: fatty acid transporter activity; long-chain-fatty-acid-CoA ligase activity
Biological Process: fatty acid transport; lipid metabolic process; long-chain fatty acid metabolic process; long-chain fatty acid transport; transport
Disease: Ichthyosis Prematurity Syndrome
Research Articles on SLC27A4
1. A) that is predicted to lead to a p.Val477Asp substitution in fatty acid transport protein 4.">We describe two siblings with ichthyosis prematurity syndrome and report a recurrent homozygous mutation (c.1430T>A) that is predicted to lead to a p.Val477Asp substitution in fatty acid transport protein 4.
Precautions
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