Short Transient Receptor Potential Channel 6 (TRPC6), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of TRPC6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9389197 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Short Transient Receptor Potential Channel 6 (TRPC6) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TRPC6. The ELISA analytical biochemical technique of the MBS9389197 kit is based on TRPC6 antibody-TRPC6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TRPC6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TRPC6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

100,106 Da

transient receptor potential cation channel subfamily C member 6

short transient receptor potential channel 6

Short transient receptor potential channel 6

TRP6; TrpC6; TRP-6  [Similar Products]

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]

TRPC6: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Interacts with MX1 and RNF24. Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q22.1

Cellular Component: cytoplasm; integral to plasma membrane; membrane; plasma membrane

Molecular Function: calcium channel activity; protein binding; store-operated calcium channel activity

Biological Process: cation transport; cytosolic calcium ion homeostasis; manganese ion transport; platelet activation; positive regulation of calcium ion transport; positive regulation of ion transmembrane transporter activity; single fertilization

Disease: Focal Segmental Glomerulosclerosis 2

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