Full Product Name
TRPC6 Antibody
Product Synonym Names
TRP6; FSGS2; FLJ11098
Product Gene Name
anti-TRPC6 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q61143
Species Reactivity
Human, Mouse, Rat
Specificity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity/Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Form/Format
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (lot specific)
Immunogen Type
Peptide-KLH
Immunogen Description
peptide Corresponding to the amino terminal sequence derived from mouse TRPC6.
Preparation and Storage
Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.
Other Notes
Small volumes of anti-TRPC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TRPC6 antibody
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).
Product Categories/Family for anti-TRPC6 antibody
Total protein Ab
Applications Tested/Suitable for anti-TRPC6 antibody
Western Blot (WB)
Application Notes for anti-TRPC6 antibody
Western blotting: 1:500~1:1000
Western Blot (WB) of anti-TRPC6 antibody
Western blot analysis of extracts from A549 and mouse brain tissue using TRPC6 antibody.
NCBI/Uniprot data below describe general gene information for TRPC6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_038866.2
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NCBI GenBank Nucleotide #
NM_013838.2
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UniProt Primary Accession #
Q61143
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UniProt Secondary Accession #
Q9Z2J1; B9EIW2[Other Products]
UniProt Related Accession #
Q61143[Other Products]
Molecular Weight
106,681 Da
NCBI Official Full Name
short transient receptor potential channel 6 isoform 1
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily C, member 6
NCBI Official Symbol
Trpc6 [Similar Products]
NCBI Official Synonym Symbols
TRP-6; Trrp6; mtrp6; AV025995; LLHWJM002; LLHWJM003; LLHWJM004
[Similar Products]
NCBI Protein Information
short transient receptor potential channel 6
UniProt Protein Name
Short transient receptor potential channel 6
UniProt Synonym Protein Names
Calcium entry channel; Transient receptor protein 6; TRP-6
Protein Family
Short transient receptor potential channel
UniProt Gene Name
Trpc6 [Similar Products]
UniProt Synonym Gene Names
Trp6; Trrp6; TrpC6; TRP-6 [Similar Products]
UniProt Entry Name
TRPC6_MOUSE
UniProt Comments for TRPC6
TRPC6: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Interacts with MX1 and RNF24. Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, cation
Cellular Component: membrane; integral to plasma membrane; integral to membrane; plasma membrane; cytosol
Molecular Function: protein binding; store-operated calcium channel activity; calcium channel activity; ion channel activity; cation channel activity
Biological Process: positive regulation of ion transmembrane transporter activity; elevation of cytosolic calcium ion concentration; transport; calcium ion transport; manganese ion transport; ion transport; positive regulation of calcium ion transport; transmembrane transport
Research Articles on TRPC6
1. L-expressing mice prevented FSGS development and inhibited tubular damage and podocyte loss induced by puromycin aminonucleoside">Gq activation stimulated calcineurin, resulting in CN-dependent TRPC6 upregulation in murine kidneys. TRPC6 deletion in GqQ>L-expressing mice prevented FSGS development and inhibited tubular damage and podocyte loss induced by puromycin aminonucleoside
Precautions
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Disclaimer
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