TRPC6, Polyclonal Antibody

Anti-TRPC6 Antibody (C-Terminus) IHC-plus; TRPC6; Transient receptor protein 6; Trrp6; TRP-6; TRP6; FSGS2; Human TRPC6

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

14 amino acid peptide from near the carboxy terminus of human TRPC6

Immunoaffinity Purified

PBS, 0.02% sodium azide.

1 mg/ml (lot specific)

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Small volumes of anti-TRPC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

TRPC ion channels, such as Transient Receptor Potential Cation Channel 6 - TRPC6 - are highly expressed cell receptors, which are activated by sodium or potassium. This receptor potential channel has been localized and expression patterns in brain cells determined using a custom TRPC6 antibody from MyBiosource. Product availabily resulted in 2013 product citations and has lead to our anti TRPC6 antibody to become a worldwide top seller. These primary antibodies rabbit polyclonal species are pan reactive to species human mouse rat and are equally detected by secondary antibodies goat anti rabbit IgG Alexa fluorâ® 405 or donkey anti rabbit Alexa 174 fluor or AMP. Fully tested after custom antibody production for human mouse ratapplications WB - western - ELISA kits development, IHC and protein IP assays, we are proud to offer this and our quality control catalogue of protein family antibodies and related monoclonal TRPC6 antibody 20 products.

Subfamily:-Calcium-channel---TRP">Family: Ion Channel
Subfamily: Calcium channel - TRP

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

IHC-P (5 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Anti-TRPC6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Immunofluorescence of TRPC6 in Mouse Lung cells with TRPC6 antibody at 20 ug/ml.

Western blot of TRPC6 in mouse lung tissue lysate with TRPC6 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.

100,106 Da

transient receptor potential cation channel, subfamily C, member 6

short transient receptor potential channel 6; TRP-6; transient receptor protein 6; focal segmental glomerulosclerosis 2

Short transient receptor potential channel 6

TRP6; TrpC6; TRP-6  [Similar Products]

TRPC6_HUMAN

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]

TRPC6: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Interacts with MX1 and RNF24. Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, cation

Chromosomal Location of Human Ortholog: 11q22.1

Cellular Component: integral to membrane; plasma membrane

Molecular Function: store-operated calcium channel activity; protein binding

Biological Process: axon guidance; platelet activation; positive regulation of ion transmembrane transporter activity; elevation of cytosolic calcium ion concentration; blood coagulation; positive regulation of calcium ion transport; transmembrane transport; cation transport; aging

Disease: Focal Segmental Glomerulosclerosis 2

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