Product Name
Connexin 47 (Gjc2), Polyclonal Antibody
Full Product Name
Connexin 47 Polyclonal Antibody
Product Synonym Names
GJC2; GJA12; Gap junction gamma-2 protein; Connexin-46.6; Cx46.6; Connexin-47; Cx47; Gap junction alpha-12 protein
Product Gene Name
anti-Gjc2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8BQU6
Purity/Purification
Antigen Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthesized peptide derived from the N-terminal region of human Connexin 47.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-Gjc2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-Gjc2 antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-Gjc2 antibody
WB: 1:500-1:2000, IF: 1:50-1:100, ELISA: 1:5000-1:20000
Western Blot (WB) of anti-Gjc2 antibody
Western Blot analysis of A549 cells with Connexin 47 Polyclonal Antibody.
NCBI/Uniprot data below describe general gene information for Gjc2. It may not necessarily be applicable to this product.
NCBI Accession #
CAC19434.1
[Other Products]
UniProt Primary Accession #
Q8BQU6
[Other Products]
UniProt Secondary Accession #
Q6TLV2; Q8BQS2; Q9EPM1[Other Products]
UniProt Related Accession #
Q8BQU6[Other Products]
Molecular Weight
Calculated MW: 47
Observed MW: 47[Observed+MW:+47" title="Find similar products with Calculated MW: 47
Observed MW: 47">Similar Products]
NCBI Official Full Name
connexin 47
NCBI Official Synonym Full Names
gap junction protein, gamma 2
NCBI Official Symbol
Gjc2 [Similar Products]
NCBI Official Synonym Symbols
Cx47; Gja12; B230382L12Rik
[Similar Products]
NCBI Protein Information
gap junction gamma-2 protein
UniProt Protein Name
Gap junction gamma-2 protein
UniProt Synonym Protein Names
Connexin-47; Cx47; Gap junction alpha-12 protein
Protein Family
Gap junction gamma-2 protein
UniProt Gene Name
Gjc2 [Similar Products]
UniProt Synonym Gene Names
Gja12; Cx47 [Similar Products]
UniProt Entry Name
CXG2_MOUSE
UniProt Comments for Gjc2
GJA12: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. Defects in GJC2 are the cause of leukodystrophy hypomyelinating type 2 (HLD2); also known as Pelizaeus-Merzbacher-like disease autosomal recessive type 1. HLD2 is an autosomal recessive hypomyelinating leukodystrophy characterized by nystagmus, impaired motor development, ataxia, choreoathetotic movements, dysarthria and progressive spasticity. Defects in GJC2 are the cause of spastic paraplegia autosomal recessive type 44 (SPG44). A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Defects in GJC2 are the cause of lymphedema hereditary type 1C (LMPH1C). LMPH1C is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment. Belongs to the connexin family. Gamma-type subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: cell junction; connexon complex; gap junction; integral to membrane; membrane; myelin sheath; plasma membrane
Molecular Function: gap junction channel activity
Biological Process: cell communication; cell-cell signaling; response to toxin
Research Articles on Gjc2
1. This study demonistrated that Cx30/Cx47 double-deficient mice has the functional role of both connexins for interastrocytic, interoligodendrocytic, and panglial coupling, and show that both connexins are required for maintenance of myelin.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
