C-C motif chemokine 4 protein (CCL4), Active Protein

G-26 T-lymphocyte-secreted protein; Lymphocyte activation gene 1 protein; LAG-1; MIP-1-beta1-69

For Research Use Only. Not for use in diagnostic procedures.

E Coli

>=96% as determined by SDS-PAGE and HPLC. (lot specific)

Lyophilized

Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Refer to the datasheet for activity details. For other activity applications, researchers should evaluate this protein for suitability in their model system.

Small volumes of CCL4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. {ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:12070155, ECO:0000269|PubMed:8525373}.

Biological Active Protein; Immunology; Chemokine

(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)

7.8 kDa

C-C motif chemokine ligand 4

C-C motif chemokine 4

C-C motif chemokine 4

LAG1; MIP1B; SCYA4; LAG-1; MIP-1-beta; ACT-2  [Similar Products]

The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]

CCL4: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular region; extracellular space

Molecular Function: CCR1 chemokine receptor binding; CCR5 chemokine receptor binding; chemokine activity; cytokine activity; identical protein binding; protein binding

Biological Process: cell adhesion; cell motility; cell-cell signaling; establishment and/or maintenance of cell polarity; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of calcium ion transport; positive regulation of calcium-mediated signaling; positive regulation of GTPase activity; response to toxin; response to virus; signal transduction

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