Product Name
Sodium bicarbonate transporter-like protein 11 (Slc4a11), Recombinant Protein
Full Product Name
Recombinant Mouse Sodium bicarbonate transporter-like protein 11 (Slc4a11) , partial
Product Gene Name
Slc4a11 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MSQNEHCQDS GEYFSAGTQG YFKNNMEDNL EVREDSLGDE VFDTVNSSIV SGESIRFFVN VNLEVQPSKS DLEAATGGCV LLHTSRKYLK LKNFEEEVRA HRDLDGFLAQ ASIILNETAT SLDDVLRTML NRFALDPNHA EPDCDLDLLM AKLFTDAGAP MESKVHLLSD TIQGVTATVR GVQYEQSWLC IICTMKTLQK RHVCISRLVR PQNWGENSCE VRFVILVLAP PKMKSTKTAM EVARTFATMF SDITFRQKLL KTRTEEEFKE ALVHQRQLLT MMMPRAAGHS MSSLHTHRHP QPPKCKDFFP FGKGIWMDIM RRFPVYPMDF TDGIIGKSKS VGKYVTTTLF LYFACLLPTI AFGSLNDENT NGAIDVQKTI AGQSIGGLLY ALFSGQPLVI LLTTAPLAIY TQVIRVICDD YNLDFNAFYA WTGLWNSFFL ALYAFLNLSL LMNLFKRSTE EIIALFISIT FVLDAVKGMV KIFGKYYYGH HYHTKRTSSL VSLLGIGRSP NSSLHTALNA SLLASPVEMA TTSSPGSTHS GQATAVLSLL IMLGTLWLGY TLYQFKKSPY LHPCVRETLS DCALPIAVLS FSLIGSYGFQ EIEMSKFRYN PSESLFEVAQ IHSLSFKAIG SAMGLGFLLS LLFFIEQNLV AALVNAPENR LVKGTAYHWD LLLLAIINTG LSLFGLPWIH AAYPHSPLHV RALALVEERV ENGHIYETIV DVKETRLTAL GASVLVGLSL LLLPFPLQWI PKPVLYGLFL YIALTSLDGN QLFSRVALLL KEQTSYPPTH YIRRVPQRKI HYFTGLQILQ LLLLCAFGMS SLPYMKMVFP LIMIAMIPIR YNLLPRIIEA KYLDVMDAEH RP
3D Structure
ModBase 3D Structure for A2AJN7
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mus musculus (Mouse)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Slc4a11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Slc4a11. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001074631.1
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NCBI GenBank Nucleotide #
NM_001081162.1
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UniProt Primary Accession #
A2AJN7
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UniProt Secondary Accession #
Q0VG86; Q3URQ1[Other Products]
UniProt Related Accession #
A2AJN7[Other Products]
Molecular Weight
96,751 Da
NCBI Official Full Name
sodium bicarbonate transporter-like protein 11
NCBI Official Synonym Full Names
solute carrier family 4, sodium bicarbonate transporter-like, member 11
NCBI Official Symbol
Slc4a11 [Similar Products]
NCBI Official Synonym Symbols
BTR1; NaBC1; AI503023
[Similar Products]
NCBI Protein Information
sodium bicarbonate transporter-like protein 11
UniProt Protein Name
Sodium bicarbonate transporter-like protein 11
UniProt Synonym Protein Names
Bicarbonate transporter-related protein 1; Sodium borate cotransporter 1; NaBC1; Solute carrier family 4 member 11
Protein Family
Sodium bicarbonate transporter-like protein
UniProt Gene Name
Slc4a11 [Similar Products]
UniProt Synonym Gene Names
BTR1; NaBC1 [Similar Products]
UniProt Comments for Slc4a11
Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration. Involved in borate homeostasis. In the absence of borate, it functions as a Na+ and OH-(H+) channel. In the presence of borate functions as an electrogenic Na+ coupled borate cotransporter.
Research Articles on Slc4a11
1. Results provide evidence for a critical role of Vps35 in mouse corneal dystrophy; suggest that SLC4A11 appears to be a Vps35/retromer cargo, and Vps35-regulation of SLC4A11 trafficking may underlie Vps35/retromer regulation of corneal dystrophy.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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