Bruton'S Tyrosine Kinase, ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: X; NC_000023.10 (100604435..100641212, complement). Location: Xq21.33-q22

Store all reagents at 2-8 degree C

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Small volumes of BTK elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS009949 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Bruton'S Tyrosine Kinase (BTK) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing BTK. The ELISA analytical biochemical technique of the MBS009949 kit is based on BTK antibody-BTK antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect BTK antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, BTK. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

76,281 Da

Bruton agammaglobulinemia tyrosine kinase

tyrosine-protein kinase BTK; B-cell progenitor kinase; agammaglobulinaemia tyrosine kinase; tyrosine-protein kinase BTK isoform (lacking exon 14); dominant-negative kinase-deficient Brutons tyrosine kinase

Tyrosine-protein kinase BTK

AGMX1; ATK; BPK; ATK; BPK  [Similar Products]

BTK_HUMAN

The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. [provided by RefSeq, Nov 2008]

Btk: a tyrosine kinase of the Tec family. Plays a crucial role in B-cell ontogeny. Defects cause X-linked agammaglobulinemia, an immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. Truncated splice forms found in childhood leukemias may underlie radiation resistance of tumors through inhibition of apoptosis.

Protein type: Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; EC 2.7.10.2; TK group; Tec family

Chromosomal Location of Human Ortholog: Xq21.33-q22

Cellular Component: extrinsic to internal side of plasma membrane; mast cell granule; intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasm; plasma membrane; cytoplasmic vesicle; nucleus; cytosol; lipid raft

Molecular Function: identical protein binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; metal ion binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; adaptive immune response; transcription, DNA-dependent; B cell activation; cell maturation; calcium-mediated signaling; T cell receptor signaling pathway; protein amino acid phosphorylation; toll-like receptor 2 signaling pathway; regulation of cell proliferation; activation of NF-kappaB transcription factor; regulation of B cell cytokine production; regulation of B cell apoptosis; MyD88-dependent toll-like receptor signaling pathway; B cell receptor signaling pathway; histamine secretion by mast cell; toll-like receptor signaling pathway; positive regulation of B cell differentiation; innate immune response; mesoderm development; cell differentiation; toll-like receptor 4 signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Isolated Growth Hormone Deficiency, Type Iii; Agammaglobulinemia, X-linked

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