Product Name
MATN3, Blocking Peptide
Full Product Name
MATN3 Peptide
Product Synonym Names
HOA; OS2; EDM5; DIPOA; OADIP; Matrilin-3; matrilin 3
Product Gene Name
MATN3 blocking peptide
[Similar Products]
MATN3 peptide (MBS152520) is used for blocking the activity of MATN3 antibody (MBS150370)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O15232
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
13 amino acids near the center of human MATN3.
Preparation and Storage
Store MATN3 peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of MATN3 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for MATN3 blocking peptide
Blocking (BL)
Application Notes for MATN3 blocking peptide
MATN3 peptide is used for blocking the activity of MATN3 antibody.
NCBI/Uniprot data below describe general gene information for MATN3. It may not necessarily be applicable to this product.
NCBI Accession #
AAI39908
[Other Products]
UniProt Primary Accession #
O15232
[Other Products]
UniProt Secondary Accession #
Q4ZG02; B2CPU0[Other Products]
UniProt Related Accession #
O15232[Other Products]
Molecular Weight
48,317 Da
NCBI Official Full Name
Matrilin 3
NCBI Official Synonym Full Names
matrilin 3
NCBI Official Symbol
MATN3 [Similar Products]
NCBI Official Synonym Symbols
HOA; OS2; EDM5; DIPOA; OADIP
[Similar Products]
NCBI Protein Information
matrilin-3
UniProt Protein Name
Matrilin-3
UniProt Gene Name
MATN3 [Similar Products]
UniProt Entry Name
MATN3_HUMAN
NCBI Summary for MATN3
This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains two von Willebrand factor A domains; it is present in the cartilage extracellular matrix and has a role in the development and homeostasis of cartilage and bone. Mutations in this gene result in multiple epiphyseal dysplasia. [provided by RefSeq, Jul 2008]
UniProt Comments for MATN3
MATN3: Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks. Defects in MATN3 are the cause of multiple epiphyseal dysplasia type 5 (EDM5). EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types. EDM5 is relatively mild and clinically variable. It is primarily characterized by delayed and irregular ossification of the epiphyses and early-onset osteoarthritis. Defects in MATN3 are the cause of spondyloepimetaphyseal dysplasia MATN3-related (SEMD-MATN3). A bone disease characterized by disproportionate early-onset dwarfism, bowing of the lower limbs, lumbar lordosis and normal hands. Skeletal abnormalities include short, wide and stocky long bones with severe epiphyseal and metaphyseal changes, hypoplastic iliac bones and flat, ovoid vertebral bodies. Genetic variations in MATN3 are associated with susceptibility to osteoarthritis type 2 (OS2); also called osteoarthritis of distal interphalangeal joints (OADIP) or hand osteoarthritis (HOA). Osteoarthritis is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. In the hand, osteoarthritis can develop in the distal interphalangeal and the first carpometacarpal (base of thumb) and proximal interphalangeal joints. Patients with osteoarthritis may have one, a few, or all of these sites affected.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 2p24-p23
Cellular Component: proteinaceous extracellular matrix; extracellular region
Molecular Function: protein binding; extracellular matrix structural constituent
Biological Process: extracellular matrix organization and biogenesis; skeletal development
Disease: Osteoarthritis Susceptibility 2; Spondyloepimetaphyseal Dysplasia, Matrilin-3 Related; Epiphyseal Dysplasia, Multiple, 5
Research Articles on MATN3
1. The VWA1 domain of matrilin-3 is primarily responsible for the induction of IL-6 release from primary human chondrocytes.
Precautions
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Disclaimer
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