Product Name
Slc5a2, Blocking Peptide
Full Product Name
Slc5a2 Peptide - middle region
Product Gene Name
Slc5a2 blocking peptide
[Similar Products]
Product Synonym Gene Name
Sglt2[Similar Products]
Slc5a2 peptide (MBS3232019) is used for blocking the activity of Slc5a2 antibody (MBS3207053)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
SSTCYQPRPD SYHLLRDPVT GDLPWPALLL GLTIVSGWYW CSDQVIVQRC
3D Structure
ModBase 3D Structure for Q923I7
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of Slc5a2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Slc5a2 blocking peptide
This is a synthetic peptide designed for use in combination with anti-Slc5a2 Antibody, made
Target Description: Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.
Product Categories/Family for Slc5a2 blocking peptide
Peptide
Applications Tested/Suitable for Slc5a2 blocking peptide
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for Slc5a2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_573517
[Other Products]
NCBI GenBank Nucleotide #
NM_133254
[Other Products]
UniProt Primary Accession #
Q923I7
[Other Products]
UniProt Related Accession #
Q923I7[Other Products]
NCBI Official Full Name
sodium/glucose cotransporter 2
NCBI Official Synonym Full Names
solute carrier family 5 (sodium/glucose cotransporter), member 2
NCBI Official Symbol
Slc5a2 [Similar Products]
NCBI Official Synonym Symbols
Sglt2
[Similar Products]
NCBI Protein Information
sodium/glucose cotransporter 2
UniProt Protein Name
Sodium/glucose cotransporter 2
UniProt Synonym Protein Names
Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2
Protein Family
Sodium/glucose cotransporter
UniProt Gene Name
Slc5a2 [Similar Products]
UniProt Synonym Gene Names
Sglt2; Na(+)/glucose cotransporter 2 [Similar Products]
UniProt Entry Name
SC5A2_MOUSE
UniProt Comments for Slc5a2
SLC5A2: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1. Defects in SLC5A2 are the cause of renal glucosuria (GLYS1). GLYS1 is an autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral
Cellular Component: brush border membrane; integral to membrane; membrane
Molecular Function: glucose:sodium symporter activity; protein binding; symporter activity; transporter activity
Biological Process: carbohydrate transport; glucose transport; ion transport; sodium ion transport; transmembrane transport; transport
Research Articles on Slc5a2
1. An inhibitor of the renal sodium/glucose cotransporter 2 (SGLT2), dapagliflozin, successfully prevented the development of cardiomyopathy in SKO mice. This is particularly relevant, given that SGLT2i treatment reduces cardiovascular event in T2DM patients. [review]
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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