Full Product Name
Rabbit SLC5A2 Antibody
Product Gene Name
anti-SLC5A2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 16; NC_000016.9 (31494439..31502091). Location: 16p11.2
3D Structure
ModBase 3D Structure for P31639
Species Reactivity
Human, mouse, rat
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-SLC5A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SLC5A2 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for SLC5A2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003032.1
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NCBI GenBank Nucleotide #
NM_003041.3
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UniProt Primary Accession #
P31639
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UniProt Related Accession #
P31639[Other Products]
Molecular Weight
72,897 Da
NCBI Official Full Name
sodium/glucose cotransporter 2
NCBI Official Synonym Full Names
solute carrier family 5 (sodium/glucose cotransporter), member 2
NCBI Official Symbol
SLC5A2 [Similar Products]
NCBI Official Synonym Symbols
SGLT2
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NCBI Protein Information
sodium/glucose cotransporter 2; Na(+)/glucose cotransporter 2; solute carrier family 5 member 2; low affinity sodium-glucose cotransporter; solute carrier family 5 (sodium/glucose transporter), member 2
UniProt Protein Name
Sodium/glucose cotransporter 2
UniProt Synonym Protein Names
Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2
Protein Family
Sodium/glucose cotransporter
UniProt Gene Name
SLC5A2 [Similar Products]
UniProt Synonym Gene Names
SGLT2; Na(+)/glucose cotransporter 2 [Similar Products]
UniProt Entry Name
SC5A2_HUMAN
NCBI Summary for SLC5A2
This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. [provided by RefSeq, Sep 2009]
UniProt Comments for SLC5A2
SLC5A2: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1. Defects in SLC5A2 are the cause of renal glucosuria (GLYS1). GLYS1 is an autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Protein type: Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: plasma membrane; integral to membrane
Molecular Function: low-affinity glucose:sodium symporter activity
Biological Process: transport; sodium ion transport; carbohydrate metabolic process; glucose transport; transmembrane transport
Disease: Renal Glucosuria
Research Articles on SLC5A2
1. It was concluded that human SGLT1 and SGLT2 are regulated by different mechanisms and suggest that insulin is an SGLT2 agonist in vivo.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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