CACNB2, Monoclonal Antibody

Anti -CACNB2 (Calcium Channel Voltage-dependent beta 2 Subunit, CAB2, CACNLB2, CAVB2, FLJ23743, Lambert-Eaton Myasthenic Syndrome Antigen B, Myasthenic (Lambert-Eaton) Syndrome Antigen B, MYSB, Voltage-dependent L-type Calcium Channel Subunit beta 2)

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1

10F683

Mouse

Recognizes rat Cavb2. Species Crossreactivity: human. No cross reactivity against Cavb1, Cavb3, Cavb4.

Affinity Purified
Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, pH7.4, 50% glycerol and 0.09% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-CACNB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand-gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium

Antibodies; Abs to Disease Markers

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry.
Dilution: Western Blot:1-10ug/ml
Immunohistochemistry:0.1-1ug/ml

68,326 Da[Similar Products]

Calcium channel, voltage-dependent, beta 2 subunit

A6PVM7_HUMAN

CACNB2: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRGDA4). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel beta subunit family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium

Chromosomal Location of Human Ortholog: 10p12

Cellular Component: integral to plasma membrane; voltage-gated calcium channel complex; sarcolemma

Molecular Function: voltage-gated calcium channel activity; protein binding; calcium channel activity; high voltage-gated calcium channel activity

Biological Process: axon guidance; synaptic transmission; visual perception; transport; positive regulation of calcium ion transport; neuromuscular junction development

Disease: Brugada Syndrome 4

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