Full Product Name
SGCA Antibody
Product Synonym Names
Alpha-sarcoglycan; Alpha-SG; Adhalin; 50 kDa dystrophin-associated glycoprotein; 50DAG; Dystroglycan-2
Product Gene Name
anti-SGCA antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q16586
Species Reactivity
Human, Mouse
Specificity
SGCA Antibody detects endogenous levels of total SGCA protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human SGCA.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-SGCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SGCA antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-SGCA antibody
WB: 1:500~1:1000
ELISA: 1:40000
Western Blot (WB) of anti-SGCA antibody
Western blot analysis of lysates from HeLa, HepG2, and Jurkat cells, using SGCA Antibody. The lane on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for SGCA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000014.1
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NCBI GenBank Nucleotide #
NM_000023.3
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UniProt Primary Accession #
Q16586
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UniProt Secondary Accession #
Q13710; Q13712; A6NEB8; A8K3K7[Other Products]
UniProt Related Accession #
Q16586[Other Products]
NCBI Official Full Name
alpha-sarcoglycan isoform 1
NCBI Official Synonym Full Names
sarcoglycan alpha
NCBI Official Symbol
SGCA [Similar Products]
NCBI Official Synonym Symbols
ADL; DAG2; 50DAG; DMDA2; LGMD2D; SCARMD1; adhalin
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NCBI Protein Information
alpha-sarcoglycan
UniProt Protein Name
Alpha-sarcoglycan
UniProt Synonym Protein Names
50 kDa dystrophin-associated glycoprotein; 50DAG; Adhalin; Dystroglycan-2
Protein Family
Alpha-sarcoglycan
UniProt Gene Name
SGCA [Similar Products]
UniProt Synonym Gene Names
ADL; DAG2; Alpha-SG; 50DAG [Similar Products]
NCBI Summary for SGCA
This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
UniProt Comments for SGCA
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Research Articles on SGCA
1. Pathogenic mutations were found in SGCA from Egyptian families with limb-girdle muscular dystrophy.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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