Full Product Name
Rabbit Amylin Antibody
Product Gene Name
anti-IAPP antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 12; NC_000012.11 (21525802..21532914). Location: 12p12.1
3D Structure
ModBase 3D Structure for P10997
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-IAPP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-IAPP antibody
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for IAPP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000406.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000415.2
[Other Products]
UniProt Primary Accession #
P10997
[Other Products]
UniProt Secondary Accession #
Q0ZD87; Q14598[Other Products]
UniProt Related Accession #
P10997[Other Products]
Molecular Weight
9,806 Da[Similar Products]
NCBI Official Full Name
islet amyloid polypeptide
NCBI Official Synonym Full Names
islet amyloid polypeptide
NCBI Official Symbol
IAPP [Similar Products]
NCBI Official Synonym Symbols
DAP; IAP
[Similar Products]
NCBI Protein Information
islet amyloid polypeptide; amylin; insulinoma amyloid peptide; diabetes-associated peptide; Islet amyloid polypeptide (diabetes-associated peptide; amylin)
UniProt Protein Name
Islet amyloid polypeptide
UniProt Synonym Protein Names
Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide
Protein Family
Islet amyloid polypeptide
UniProt Gene Name
IAPP [Similar Products]
UniProt Synonym Gene Names
DAP [Similar Products]
UniProt Entry Name
IAPP_HUMAN
NCBI Summary for IAPP
Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. [provided by RefSeq, Apr 2011]
UniProt Comments for IAPP
IAPP: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Belongs to the calcitonin family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 12p12.1
Cellular Component: extracellular space; cell soma; extracellular region
Molecular Function: identical protein binding; hormone activity; receptor binding
Biological Process: negative regulation of cell differentiation; cell-cell signaling; apoptosis; eating behavior; signal transduction; sensory perception of pain; negative regulation of bone resorption; endocrine pancreas development
Research Articles on IAPP
1. Studies indicate that IAPP is one of the most amyloidogenic sequences known.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
