FAT tumor suppressor homolog 4, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to FAT4.

Affinity purified

1*TBS (pH7.4), 0.5%BSA, 25% Glycerol.

Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.

Small volumes of anti-FAT4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Protocadherin Fat 4 is a single-pass type I membrane protein that widely expressed in fetal brain, infant brain, brain tumor and colorectal cancer. Cadherins are cell-cell interaction molecules. FAT4 may play the role in the regulation of planar cell polarity.

Western Blot (WB), Immunocytochemistry (ICC)

WB: 1:500-1:1,000
ICC: 1:50-1:100

Western blot analysis on recombinant FAT4 using anti-FAT4 polyclonal antibody.

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The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP). Studies in mice suggest that loss of PCP signaling may cause cystic kidney disease, and mutations in this gene have been associated with Van Maldergem Syndrome 2. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Mar 2014]

Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation ().

1. "Comparative integromics on FAT1, FAT2, FAT3 and FAT4."Katoh Y., Katoh M.Int. J. Mol. Med. 18:523-528(2006). 2. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.Cancer Lett. 197:63-68(2003).

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