Full Product Name
FAT4 Antibody
Product Synonym Names
Protocadherin Fat 4; hFat4; Cadherin family member 14; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; FAT4; CDHF14; FATJ; Nbla00548
Product Gene Name
anti-FAT4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q6V0I7
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant human Protocadherin Fat 4 protein
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-FAT4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FAT4 antibody
Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity).
Applications Tested/Suitable for anti-FAT4 antibody
ELISA (EIA), Immunofluorescence (IF)
Immunofluorescence (IF) of anti-FAT4 antibody
Immunofluorescent analysis of HepG-2 cells using MBS7044344 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
NCBI/Uniprot data below describe general gene information for FAT4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001278214.1
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NCBI GenBank Nucleotide #
NM_001291285.1
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UniProt Primary Accession #
Q6V0I7
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UniProt Secondary Accession #
Q3LIA6; Q8TCK7; Q9H5T6; A8K5Z6; B5MDG4[Other Products]
UniProt Related Accession #
Q6V0I7[Other Products]
Molecular Weight
542,616 Da
NCBI Official Full Name
protocadherin Fat 4 isoform 2
NCBI Official Synonym Full Names
FAT atypical cadherin 4
NCBI Official Symbol
FAT4 [Similar Products]
NCBI Official Synonym Symbols
FATJ; FAT-J; CDHF14; CDHR11; HKLLS2; VMLDS2; NBLA00548
[Similar Products]
NCBI Protein Information
protocadherin Fat 4
UniProt Protein Name
Protocadherin Fat 4
UniProt Synonym Protein Names
Cadherin family member 14; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J
Protein Family
Protocadherin
UniProt Gene Name
FAT4 [Similar Products]
UniProt Synonym Gene Names
CDHF14; FATJ; hFat4 [Similar Products]
UniProt Entry Name
FAT4_HUMAN
NCBI Summary for FAT4
The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP). Studies in mice suggest that loss of PCP signaling may cause cystic kidney disease, and mutations in this gene have been associated with Van Maldergem Syndrome 2. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Mar 2014]
UniProt Comments for FAT4
FAT4: May function in the regulation of planar cell polarity. Cadherins are cell-cell interaction molecules. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 4q28.1
Molecular Function: protein binding
Biological Process: cerebral cortex development; heterophilic cell adhesion; neurogenesis
Disease: Hennekam Lymphangiectasia-lymphedema Syndrome 2; Van Maldergem Syndrome 2
Research Articles on FAT4
1. FAT4 has a tumour suppressor role mediated by the modulation of Wnt/beta-catenin signalling, providing potential novel targets for the treatment of gastric cancer
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
