Full Product Name
TIRAP (phospho Tyr86) Polyclonal Antibody
Product Gene Name
anti-TIRAP antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P58753
Other Notes
Small volumes of anti-TIRAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TIRAP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001034750.1
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NCBI GenBank Nucleotide #
NM_001039661.1
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UniProt Primary Accession #
P58753
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UniProt Secondary Accession #
Q56UH9; Q56UI0; Q8N5E5; B3KW65[Other Products]
UniProt Related Accession #
P58753[Other Products]
Molecular Weight
27,948 Da
NCBI Official Full Name
toll/interleukin-1 receptor domain-containing adapter protein isoform a
NCBI Official Synonym Full Names
TIR domain containing adaptor protein
NCBI Official Symbol
TIRAP [Similar Products]
NCBI Official Synonym Symbols
Mal; wyatt; BACTS1; MyD88-2
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NCBI Protein Information
toll/interleukin-1 receptor domain-containing adapter protein
UniProt Protein Name
Toll/interleukin-1 receptor domain-containing adapter protein
UniProt Synonym Protein Names
Adaptor protein Wyatt; MyD88 adapter-like protein; MyD88-2
Protein Family
Toll/interleukin-1 receptor domain-containing adapter protein
UniProt Gene Name
TIRAP [Similar Products]
UniProt Synonym Gene Names
MAL; TIR domain-containing adapter protein; MyD88-2 [Similar Products]
NCBI Summary for TIRAP
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
UniProt Comments for TIRAP
Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
Research Articles on TIRAP
1. The major allele A of rs2511521 located in DRD2 and the minor allele T of rs625413 located in TIRAP are significantly associated with increased risk of food addiction in overweight/obese subjects with low/zero food addiction symptoms.
Precautions
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Disclaimer
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