Full Product Name
MSX2 Antibody
Product Synonym Names
CRS2; FPP; Homeobox protein Hox-8; Homeobox protein MSX-2; HOX8; MSH; msh homeo box 2; msh homeobox 2; msh homeobox homolog 2; MSX2; PFM; PFM1
Product Gene Name
anti-MSX2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P35548
Species Reactivity
Human, Mouse
Specificity
MSX2 antibody detects endogenous levels of total MSX2protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from Internal of human MSX2.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-MSX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-MSX2 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-MSX2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-MSX2 antibody
WB: 1:500~1:1000
ELISA: 1:20000
Testing Data of anti-MSX2 antibody
NCBI/Uniprot data below describe general gene information for MSX2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002440.2
[Other Products]
NCBI GenBank Nucleotide #
NM_002449.4
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UniProt Primary Accession #
P35548
[Other Products]
UniProt Secondary Accession #
Q53XM4; Q9UD60; D3DQN1[Other Products]
UniProt Related Accession #
P35548[Other Products]
Molecular Weight
28,897 Da
NCBI Official Full Name
homeobox protein MSX-2
NCBI Official Synonym Full Names
msh homeobox 2
NCBI Official Symbol
MSX2 [Similar Products]
NCBI Official Synonym Symbols
FPP; MSH; PFM; CRS2; HOX8; PFM1
[Similar Products]
NCBI Protein Information
homeobox protein MSX-2
UniProt Protein Name
Homeobox protein MSX-2
UniProt Synonym Protein Names
Homeobox protein Hox-8
Protein Family
Msx2-interacting protein
UniProt Gene Name
MSX2 [Similar Products]
UniProt Synonym Gene Names
HOX8 [Similar Products]
NCBI Summary for MSX2
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008]
UniProt Comments for MSX2
Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.
Product References and Citations for anti-MSX2 antibody
Hodgkinson J.E., Biochim. Biophys. Acta 1174:11-16(1993). Jabs E.W., Cell 75:443-450(1993). Iimura T., DNA Seq. 8:87-92(1997).
Research Articles on MSX2
1. MSX2 played a crucial role in the progression of colorectal cancer and may be a potential novel prognostic factor
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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