Product Name
FTCD, Blocking Peptide
Full Product Name
FTCD Peptide
Product Gene Name
FTCD blocking peptide
[Similar Products]
Product Synonym Gene Name
LCHC1[Similar Products]
FTCD peptide (MBS3230885) is used for blocking the activity of FTCD antibody (MBS3205923)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O95954
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of FTCD blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
FTCD blocking peptide
This is a synthetic peptide designed for use in combination with anti-FTCD antibody made
Target Description: FTCD is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool.FTCD is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool.[supplied by OMIM].
Product Categories/Family for FTCD blocking peptide
Peptide
Applications Tested/Suitable for FTCD blocking peptide
Immunohistochemistry (IHC), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for FTCD. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006648
[Other Products]
NCBI GenBank Nucleotide #
NM_006657
[Other Products]
UniProt Primary Accession #
O95954
[Other Products]
UniProt Related Accession #
O95954[Other Products]
NCBI Official Full Name
formimidoyltransferase-cyclodeaminase isoform A
NCBI Official Synonym Full Names
formimidoyltransferase cyclodeaminase
NCBI Official Symbol
FTCD [Similar Products]
NCBI Official Synonym Symbols
LCHC1
[Similar Products]
NCBI Protein Information
formimidoyltransferase-cyclodeaminase
UniProt Protein Name
Formimidoyltransferase-cyclodeaminase
UniProt Synonym Protein Names
Formiminotransferase-cyclodeaminase; FTCD; LCHC1Including the following 2 domains:Glutamate formimidoyltransferase (EC:2.1.2.5)Alternative name(s):Glutamate formiminotransferase; Glutamate formyltransferase
Protein Family
Formimidoyltransferase-cyclodeaminase
UniProt Gene Name
FTCD [Similar Products]
UniProt Synonym Gene Names
FTCD [Similar Products]
UniProt Entry Name
FTCD_HUMAN
NCBI Summary for FTCD
The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009]
UniProt Comments for FTCD
FTCD: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency (FIGLU-URIA); also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Methyltransferase; EC 4.3.1.4; EC 2.1.2.5; Lyase; Cofactor and Vitamin Metabolism - one carbon pool by folate; Amino Acid Metabolism - histidine
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: centriole; Golgi apparatus; cytoplasm; cytosol
Molecular Function: formimidoyltetrahydrofolate cyclodeaminase activity; glutamate formimidoyltransferase activity; folic acid binding
Biological Process: folic acid and derivative metabolic process; cytoskeleton organization and biogenesis; histidine catabolic process to glutamate and formamide; histidine catabolic process; histidine catabolic process to glutamate and formate
Disease: Formiminotransferase Deficiency
Research Articles on FTCD
1. The rs914246 variant, but not the rs914245 variant, of the FTCD gene modulated accuracy in the task for younger, but not older, people under high working memory
Precautions
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Disclaimer
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