FTCD, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Goat

This item detects an epitope within the N-terminal (NT) region of formiminotransferase cyclodeaminase (FTCD), also known as 58K Golgi protein. FTCD is a homo-octameric bifunctional enzyme which plays important roles in coupling histidine catabolism with folate metabolism, and integrating the Golgi complex with the vimentin intermediate filament cytoskeleton.

FTCD is present in all mammalian cells either free in the cytosol or tightly bound to the Golgi complex, and is most abundant in the liver. FTCD is linked to two human diseases, autoimmune hepatitis and glutamate formiminotransferase deficiency.

Purified
Purified IgG - liquid

IgG concentration 0.5mg/ml (lot specific)

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Small volumes of anti-FTCD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS221354 detects an epitope within the N-terminal (NT) region of formiminotransferase cyclodeaminase (FTCD), also known as 58K Golgi protein. FTCD is a homo-octameric bifunctional enzyme which plays important roles in coupling histidine catabolism with folate metabolism, and integrating the Golgi complex with the vimentin intermediate filament cytoskeleton. FTCD is present in all mammalian cells either free in the cytosol or tightly bound to the Golgi complex, and is most abundant in the liver. FTCD is linked to two human diseases, autoimmune hepatitis and glutamate formiminotransferase deficiency.

ELISA (EIA), Western Blot (WB)

Western Blot: This item detects a band of approximately 55-60kDa in human liver lysate.
ELISA: Maximum Dilution: 1/64000
Western Blotting: Minimum Dilution: 0.03; Maximum Dilution: 0.5ug/ml

16,503 Da

formimidoyltransferase cyclodeaminase

formimidoyltransferase-cyclodeaminase; formiminotransferase cyclodeaminase; formiminotransferase-cyclodeaminase

Formimidoyltransferase-cyclodeaminase

FTCD  [Similar Products]

FTCD_HUMAN

The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009]

FTCD: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency (FIGLU-URIA); also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; EC 2.1.2.5; Lyase; Amino Acid Metabolism - histidine; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 4.3.1.4

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: centriole; Golgi apparatus; cytoplasm; cytosol

Molecular Function: formimidoyltetrahydrofolate cyclodeaminase activity; glutamate formimidoyltransferase activity; folic acid binding

Biological Process: folic acid and derivative metabolic process; histidine catabolic process to glutamate and formamide; cytoskeleton organization and biogenesis; histidine catabolic process; histidine catabolic process to glutamate and formate

Disease: Formiminotransferase Deficiency

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.