Full Product Name
FTCD antibody
Product Gene Name
anti-FTCD antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Purified by antigen-affinity chromatography.
Form/Format
Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Immunogen Type
Recombinant protein
Immunogen Description
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 221 of FTCD
Preparation and Storage
Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.
Other Notes
Small volumes of anti-FTCD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FTCD antibody
FTCD is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool.[supplied by OMIM]
Product Categories/Family for anti-FTCD antibody
Total protein Ab
Applications Tested/Suitable for anti-FTCD antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-FTCD antibody
Western blotting: 1:500-1:3000
Immunohistochemistry: 1:100-1:500
Testing Data of anti-FTCD antibody
Sample (30 ug of whole cell lysate)A: Hep G2 7.5% SDS PAGEPrimary antibody diluted at 1: 1000
Immunohistochemistry (IHC) of anti-FTCD antibody
Immunohistochemical analysis of paraffin-embedded NCIN87 xenograft, using FTCD antibody at 1: 100 dilution.
NCBI/Uniprot data below describe general gene information for FTCD. It may not necessarily be applicable to this product.
NCBI Accession #
NP_996848
[Other Products]
NCBI GenBank Nucleotide #
NM_206965.1
[Other Products]
UniProt Secondary Accession #
Q86V03; Q9HCT4; Q9HCT5; Q9HCT6; Q9UHJ2; B9EGD0[Other Products]
UniProt Related Accession #
O95954[Other Products]
Molecular Weight
16,503 Da
NCBI Official Full Name
formimidoyltransferase-cyclodeaminase
NCBI Official Synonym Full Names
formimidoyltransferase cyclodeaminase
NCBI Official Symbol
FTCD [Similar Products]
NCBI Official Synonym Symbols
LCHC1
[Similar Products]
NCBI Protein Information
formimidoyltransferase-cyclodeaminase
UniProt Protein Name
Formimidoyltransferase-cyclodeaminase
UniProt Synonym Protein Names
Formiminotransferase-cyclodeaminase; FTCD; LCHC1Including the following 2 domains:Glutamate formimidoyltransferase (EC:2.1.2.5)Alternative name(s):Glutamate formiminotransferase; Glutamate formyltransferase
Protein Family
Formimidoyltransferase-cyclodeaminase
UniProt Gene Name
FTCD [Similar Products]
UniProt Synonym Gene Names
FTCD [Similar Products]
UniProt Entry Name
FTCD_HUMAN
NCBI Summary for FTCD
The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009]
UniProt Comments for FTCD
FTCD: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency (FIGLU-URIA); also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - histidine; Methyltransferase; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 4.3.1.4; EC 2.1.2.5; Lyase
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: centriole; cytoplasm; cytosol; endoplasmic reticulum; ER-Golgi intermediate compartment; Golgi apparatus; Golgi membrane; smooth endoplasmic reticulum membrane
Molecular Function: folic acid binding; formimidoyltetrahydrofolate cyclodeaminase activity; formimidoyltransferase activity; glutamate formimidoyltransferase activity; microtubule binding; protein binding
Biological Process: cytoskeleton organization and biogenesis; folic acid and derivative metabolic process; histidine catabolic process; histidine catabolic process to glutamate and formamide; histidine catabolic process to glutamate and formate
Disease: Formiminotransferase Deficiency
Research Articles on FTCD
1. FTCD is a positive regulator of the hypoxia-HIF signaling pathway and has an important role in cell proliferation, metabolism and migration in HepG2 cells
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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