Full Product Name
MMP20 Polyclonal Antibody
Product Gene Name
anti-MMP20 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O60882
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
A synthetic peptide of human MMP20
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-MMP20 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-MMP20 antibody
Polyclonal
Applications Tested/Suitable for anti-MMP20 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-MMP20 antibody
WB: 1:500 - 1:2000, IHC: 1:20 - 1:200, IF: 1:10 - 1:100
NCBI/Uniprot data below describe general gene information for MMP20. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004762.2
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NCBI GenBank Nucleotide #
NM_004771.3
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UniProt Primary Accession #
O60882
[Other Products]
UniProt Secondary Accession #
Q6DKT9[Other Products]
UniProt Related Accession #
O60882[Other Products]
Molecular Weight
Calculated MW: 54kDa
NCBI Official Full Name
matrix metalloproteinase-20 preproprotein
NCBI Official Synonym Full Names
matrix metallopeptidase 20
NCBI Official Symbol
MMP20 [Similar Products]
NCBI Official Synonym Symbols
AI2A2; MMP-20
[Similar Products]
NCBI Protein Information
matrix metalloproteinase-20
UniProt Protein Name
Matrix metalloproteinase-20
UniProt Synonym Protein Names
Enamel metalloproteinase; Enamelysin
Protein Family
Matrix metalloproteinase
UniProt Gene Name
MMP20 [Similar Products]
UniProt Synonym Gene Names
MMP-20 [Similar Products]
UniProt Entry Name
MMP20_HUMAN
NCBI Summary for MMP20
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]
UniProt Comments for MMP20
MMP20: Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2). AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. Belongs to the peptidase M10A family.
Protein type: Secreted; Protease; EC 3.4.24.-; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q22.3
Cellular Component: extracellular region; extracellular space; proteinaceous extracellular matrix
Molecular Function: calcium ion binding; metalloendopeptidase activity; protein binding; zinc ion binding
Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; protein catabolic process; proteolysis
Disease: Amelogenesis Imperfecta, Hypomaturation Type, Iia2
Research Articles on MMP20
1. The growth of choroidal neovascularization in AMD would be affected by 2 genes: MMP20, a newly confirmed gene expressed in the retina, and ARMS2/HTRA1, a well-known susceptibility gene for AMD.
Precautions
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Disclaimer
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