Product Name
TRPA1, Polyclonal Antibody
Popular Item
Full Product Name
TRPA1 Polyclonal Antibody
Product Synonym Names
ANKTM1; FEPS
Product Gene Name
anti-TRPA1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O75762
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purification
Immunogen
A synthetic peptide of human TRPA1
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-TRPA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TRPA1 antibody
The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.
Product Categories/Family for anti-TRPA1 antibody
Primary antibody
Applications Tested/Suitable for anti-TRPA1 antibody
Western Blot (WB)
Application Notes for anti-TRPA1 antibody
WB: 1:500 - 1:2000
Western Blot (WB) of anti-TRPA1 antibody
Western blot analysis of extracts of various cell lines, using TRPA1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
NCBI/Uniprot data below describe general gene information for TRPA1. It may not necessarily be applicable to this product.
NCBI Accession #
O75762.3
[Other Products]
UniProt Primary Accession #
O75762
[Other Products]
UniProt Secondary Accession #
A6NIN6[Other Products]
UniProt Related Accession #
O75762[Other Products]
NCBI Official Full Name
Transient receptor potential cation channel subfamily A member 1
NCBI Official Synonym Full Names
transient receptor potential cation channel subfamily A member 1
NCBI Official Symbol
TRPA1 [Similar Products]
NCBI Official Synonym Symbols
FEPS; ANKTM1
[Similar Products]
NCBI Protein Information
transient receptor potential cation channel subfamily A member 1
UniProt Protein Name
Transient receptor potential cation channel subfamily A member 1
UniProt Synonym Protein Names
Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120
Protein Family
Transient receptor potential cation channel subfamily
UniProt Gene Name
TRPA1 [Similar Products]
UniProt Synonym Gene Names
ANKTM1 [Similar Products]
NCBI Summary for TRPA1
The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]
UniProt Comments for TRPA1
TRPA1: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system. Belongs to the transient receptor (TC 1.A.4) family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 8q21.11
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: calcium channel activity; calcium-release channel activity; channel activity
Biological Process: ion transport; protein homotetramerization; response to organic substance; sensory perception of pain
Disease: Episodic Pain Syndrome, Familial, 1
Research Articles on TRPA1
1. data suggest that cardamonin is a selective TRPA1 antagonist, providing novel insight into the target of its anti-nociceptive activity.
Precautions
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Disclaimer
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