Full Product Name
TRPA1, Affinity Purified Antibody, Rabbit
Product Gene Name
anti-TRPA1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse
Form/Format
Affinity Purified - Liquid
Immunogen
A synthetic peptide made to a region within the N-terminus (residues 1-100) of the human TRPA1 protein. [Swiss-Prot# O75762].
Other Notes
Small volumes of anti-TRPA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TRPA1 antibody
Transient receptor potential ion channels (TRPCs) are a superfamily of six transmembrane segment-spanning, gated cation channels. TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. It is a transformation-associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation.
Product Categories/Family for anti-TRPA1 antibody
Antibodies; Neurotransmission; Transient Receptor Potential Channels; TRPA1
Applications Tested/Suitable for anti-TRPA1 antibody
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Testing Data of anti-TRPA1 antibody
Image: Western blot of TRPA1 in human brain membrane fraction.
NCBI/Uniprot data below describe general gene information for TRPA1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_015628.2
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NCBI GenBank Nucleotide #
NM_007332.2
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UniProt Secondary Accession #
A6NIN6[Other Products]
UniProt Related Accession #
O75762[Other Products]
Molecular Weight
127,501 Da
NCBI Official Full Name
transient receptor potential cation channel subfamily A member 1
NCBI Official Synonym Full Names
transient receptor potential cation channel subfamily A member 1
NCBI Official Symbol
TRPA1 [Similar Products]
NCBI Official Synonym Symbols
FEPS; ANKTM1
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NCBI Protein Information
transient receptor potential cation channel subfamily A member 1
UniProt Protein Name
Transient receptor potential cation channel subfamily A member 1
UniProt Synonym Protein Names
Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120
Protein Family
Transient receptor potential cation channel subfamily
UniProt Gene Name
TRPA1 [Similar Products]
UniProt Synonym Gene Names
ANKTM1 [Similar Products]
UniProt Entry Name
TRPA1_HUMAN
NCBI Summary for TRPA1
The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]
UniProt Comments for TRPA1
TRPA1: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system. Belongs to the transient receptor (TC 1.A.4) family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 8q13
Cellular Component: stereocilium bundle; integral to plasma membrane; plasma membrane
Molecular Function: channel activity; calcium channel activity
Biological Process: response to drug; detection of mechanical stimulus involved in sensory perception of pain; detection of chemical stimulus involved in sensory perception of pain; response to hydrogen peroxide; response to pain; ion transport; response to cold; thermoception; transmembrane transport
Disease: Episodic Pain Syndrome, Familial, 1
Research Articles on TRPA1
1. The expression of mechanosensors in human periodontal ligament (hPDL) cells was evaluated using DNA microarray analysis. Mechanical stress significantly upregulated TRPA1 mRNA.
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