Full Product Name
TRPM8, CT (C940) (Transient Receptor Potential Cation Channel Subfamily M Member 8, Long Transient Receptor Potential Channel 6, LTrpC-6, LTrpC6, Transient Receptor Potential-p8, Trp-p8, LTRPC6, TRPP8)
Product Synonym Names
Anti -TRPM8, CT (C940) (Transient Receptor Potential Cation Channel Subfamily M Member 8, Long Transient Receptor Potential Channel 6, LTrpC-6, LTrpC6, Transient Receptor Potential-p8, Trp-p8, LTRPC6, TRPP8)
Product Gene Name
anti-TRPM8 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.11 (234826043..234928166). Location: 2q37.1
3D Structure
ModBase 3D Structure for Q3YFM7
Specificity
Recognizes human TRPM8.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Immunogen
Synthetic peptide at the C-term(C940) of human TRPM8 (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-TRPM8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TRPM8 antibody
TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. It is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and involved in menthol sensation. It is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium.
Product Categories/Family for anti-TRPM8 antibody
Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-TRPM8 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TRPM8 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:10-1:50
NCBI/Uniprot data below describe general gene information for TRPM8. It may not necessarily be applicable to this product.
NCBI Accession #
NP_076985.4
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NCBI GenBank Nucleotide #
NM_024080.4
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UniProt Primary Accession #
Q3YFM7
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UniProt Related Accession #
Q3YFM7; Q7Z2W7; A0AVG2[Other Products]
Molecular Weight
127,685 Da[Similar Products]
NCBI Official Full Name
transient receptor potential cation channel subfamily M member 8
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily M, member 8
NCBI Official Symbol
TRPM8 [Similar Products]
NCBI Official Synonym Symbols
TRPP8; LTRPC6; MGC2849
[Similar Products]
NCBI Protein Information
transient receptor potential cation channel subfamily M member 8; trp-p8; LTrpC-6; OTTHUMP00000065206; transient receptor potential p8; short form of the TRPM8 cationic channel; long transient receptor potential channel 6; transient receptor potential subfamily M member 8
UniProt Protein Name
Transient receptor potential cation channel, subfamily M, member 8, isoform CRA_b
Protein Family
TRPM8 channel-associated factor
UniProt Gene Name
TRPM8 [Similar Products]
UniProt Entry Name
Q3YFM7_HUMAN
UniProt Comments for TRPM8
TRPM8: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, cation
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: endoplasmic reticulum membrane; plasma membrane; integral to membrane; lipid raft; external side of plasma membrane
Molecular Function: protein binding; protein homodimerization activity; calcium channel activity
Biological Process: cellular calcium ion homeostasis; detection of temperature stimulus; response to cold; thermoception; transmembrane transport; protein homotetramerization
Research Articles on TRPM8
1. Small molecule compounds that selectively modulate TRPM8 are beginning to emerge and will be critically valuable for better understanding the role of this channel in both physiological and pathological states
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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