Product Name
5-hydroxytryptamine receptor 1B (Htr1b), Recombinant Protein
Full Product Name
Recombinant Rat 5-hydroxytryptamine receptor 1B (Htr1b)
Product Synonym Names
Recombinant 5-hydroxytryptamine receptor 1B (Htr1b); 5-hydroxytryptamine receptor 1B; 5-HT-1B; 5-HT1B; Serotonin receptor 1B
Product Gene Name
Htr1b recombinant protein
[Similar Products]
Product Synonym Gene Name
Htr1b; 5ht1b[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MEEQGIQCAP PPPATSQTGV PLANLSHNCS ADDYIYQDSI ALPWKVLLVA LLALITLATT LSNAFVIATV YRTRKLHTPA NYLIASLAVT DLLVSILVMP ISTMYTVTGR WTLGQVVCDF WLSSDITCCT ASIMHLCVIA LDRYWAITDA VDYSAKRTPK RAAIMIVLVW VFSISISLPP FFWRQAKAEE EVLDCFVNTD HVLYTVYSTV GAFYLPTLLL IALYGRIYVE ARSRILKQTP NKTGKRLTRA QLITDSPGST SSVTSINSRV PEVPSESGSP VYVNQVKVRV SDALLEKKKL MAARERKATK TLGIILGAFI VCWLPFFIIS LVMPICKDAC WFHMAIFDFF NWLGYLNSLI NPIIYTMSNE DFKQAFHKLI RFKCTG
Chromosome Location
Chromosome: 8; NC_005107.3 (88666819..88667979, complement). Location: 8q31
3D Structure
ModBase 3D Structure for P28564
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rattus norvegicus (Rat)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Htr1b recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Htr1b. It may not necessarily be applicable to this product.
NCBI Accession #
NP_071561.1
[Other Products]
NCBI GenBank Nucleotide #
NM_022225.1
[Other Products]
UniProt Primary Accession #
P28564
[Other Products]
UniProt Related Accession #
P28564[Other Products]
Molecular Weight
43,163 Da[Similar Products]
NCBI Official Full Name
5-hydroxytryptamine receptor 1B
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
NCBI Official Symbol
Htr1b [Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 1B; 5-HT-1B; serotonin receptor 1B; 5-HT1B serotonin receptor; 5-hydroxytryptamine (serotonin ) receptor 1B; serotonin (5-hydroxytryptamine (5HT)) receptor type 1B
UniProt Protein Name
5-hydroxytryptamine receptor 1B
UniProt Synonym Protein Names
Serotonin receptor 1B
Protein Family
5-hydroxytryptamine receptor
UniProt Gene Name
Htr1b [Similar Products]
UniProt Synonym Gene Names
5ht1b; 5-HT-1B; 5-HT1B [Similar Products]
UniProt Entry Name
5HT1B_RAT
NCBI Summary for Htr1b
G-protein coupled receptor for serotonin; may have a role in learning and memory [RGD, Feb 2006]
UniProt Comments for Htr1b
5-HT(1B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral
Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane
Molecular Function: serotonin binding; serotonin receptor activity; drug binding
Biological Process: response to drug; vasoconstriction; response to toxin; drinking behavior; negative regulation of synaptic transmission, glutamatergic; response to mineralocorticoid stimulus; bone remodeling; response to cocaine; regulation of dopamine secretion; synaptic transmission; negative regulation of serotonin secretion; negative regulation of cAMP biosynthetic process; response to ethanol; serotonin receptor, adenylate cyclase inhibiting pathway; G-protein coupled receptor internalization; protein kinase C activation; feeding behavior; negative regulation of synaptic transmission, GABAergic; serotonin receptor signaling pathway; regulation of behavior
Research Articles on Htr1b
1. Data show that during epileptogenic periods following hypoxic-ischemia, both 5-HT(1A) and 5HT(1B) receptor immunoreactivities were decreased within the lesioned and the non-lesioned hippocampus.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
