A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAMTS14), E

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C.

We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team

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Small volumes of ADAMTS14 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS7224673 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAMTS14) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ADAMTS14. The ELISA analytical biochemical technique of the MBS7224673 kit is based on ADAMTS14 antibody-ADAMTS14 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ADAMTS14 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ADAMTS14. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Cardiovascular

134,205 Da

ADAM metallopeptidase with thrombospondin type 1 motif, 14

A disintegrin and metalloproteinase with thrombospondin motifs 14; ADAM-TS14; ADAMTS-14; ADAM-TS 14; metalloprotease-disintegrin protease; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14

A disintegrin and metalloproteinase with thrombospondin motifs 14

ADAM-TS 14; ADAM-TS14; ADAMTS-14  [Similar Products]

ATS14_HUMAN

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene is highly similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded protein shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript variants of this gene have been identified. They result from the use of two different promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of some transcripts has not been defined. [provided by RefSeq, Jul 2008]

ADAMTS14: Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity. 4 isoforms of the human protein are produced by alternative promoter.

Protein type: Secreted, signal peptide; EC 3.4.24.-; Motility/polarity/chemotaxis; Secreted; Protease

Chromosomal Location of Human Ortholog: 10q21

Cellular Component: proteinaceous extracellular matrix; extracellular region

Molecular Function: zinc ion binding; metalloendopeptidase activity

Biological Process: collagen catabolic process; extracellular matrix organization and biogenesis; collagen fibril organization; proteolysis

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