Full Product Name
NF1 Antibody
Product Synonym Names
Neurofibromin; Neurofibromatosis-related protein NF-1; Neurofibromin truncated; NF1
Product Gene Name
anti-NF1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P21359
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Neurofibromin protein (655-892AA)
Conjugation
Non-conjugated
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-NF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NF1 antibody
Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.
Product Categories/Family for anti-NF1 antibody
Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Metabolism; Signal transduction
Applications Tested/Suitable for anti-NF1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-NF1 antibody
IHC: 1:20-1:200
Immunohistochemistry (IHC) of anti-NF1 antibody
Immunohistochemistry of paraffin-embedded human placenta tissue using MBS7104133 at dilution of 1:100
NCBI/Uniprot data below describe general gene information for NF1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000258.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000267.3
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UniProt Primary Accession #
P21359
[Other Products]
UniProt Secondary Accession #
O00662; Q14284; Q14930; Q14931; Q9UMK3[Other Products]
UniProt Related Accession #
P21359[Other Products]
Molecular Weight
318,992 Da
NCBI Official Full Name
neurofibromin isoform 2
NCBI Official Synonym Full Names
neurofibromin 1
NCBI Official Symbol
NF1 [Similar Products]
NCBI Official Synonym Symbols
WSS; NFNS; VRNF
[Similar Products]
NCBI Protein Information
neurofibromin
UniProt Protein Name
Neurofibromin
UniProt Synonym Protein Names
Neurofibromatosis-related protein NF-1
Protein Family
Neurofibromin
UniProt Gene Name
NF1 [Similar Products]
NCBI Summary for NF1
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for NF1
Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.
Research Articles on NF1
1. this studies show the ability of miR-10b to activate the expression of c-Jun through RhoC and NF1, which represents a novel pathway for promoting migration and invasion of human cancer cells
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
