Full Product Name
BBS9 Antibody
Product Synonym Names
B1; C18; D1; MGC118917; PTHB1
Product Gene Name
anti-BBS9 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of BBS9
Calculated Molecular Weight: 99kd
Observed Molecular Weight: 60kd
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-82536 / sc-292152
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-BBS9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-BBS9 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-BBS9 antibody
WB: 1:200-1:2000
IHC: 1:20-1:200
Testing Data of anti-BBS9 antibody
NCBI/Uniprot data below describe general gene information for BBS9. It may not necessarily be applicable to this product.
NCBI Accession #
AAH32715.1
[Other Products]
UniProt Secondary Accession #
P78514; Q7KYS6; Q7KYS7; Q8N570; Q99844; Q99854; Q9Y699; Q9Y6A0; E9PDC9[Other Products]
UniProt Related Accession #
Q3SYG4[Other Products]
Molecular Weight
98,683 Da
NCBI Official Full Name
BBS9 protein
NCBI Official Synonym Full Names
Bardet-Biedl syndrome 9
NCBI Official Symbol
BBS9 [Similar Products]
NCBI Official Synonym Symbols
B1; D1; C18; PTHB1
[Similar Products]
NCBI Protein Information
protein PTHB1; PTH-responsive osteosarcoma B1 protein; bardet-Biedl syndrome 9 protein; parathyroid hormone-responsive B1 gene protein
UniProt Protein Name
Protein PTHB1
UniProt Synonym Protein Names
Bardet-Biedl syndrome 9 protein; Parathyroid hormone-responsive B1 gene protein
UniProt Gene Name
BBS9 [Similar Products]
UniProt Synonym Gene Names
PTHB1 [Similar Products]
UniProt Entry Name
PTHB1_HUMAN
NCBI Summary for BBS9
This gene is downregulated by parathyroid hormone in osteoblastic cells, and therefore, is thought to be involved in parathyroid hormone action in bones. The exact function of this gene has not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for BBS9
BBS9: The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. A chromosomal aberration involving PTHB1 is found in Wilms tumor 5 (WT5). Translocation t(1;7)(q42;p15) with OBSCN. Defects in BBS9 are a cause of Bardet-Biedl syndrome type 9 (BBS9). Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. 6 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 7p14
Cellular Component: pericentriolar material; cytosol; cilium
Molecular Function: protein binding
Biological Process: fat cell differentiation; protein transport; visual perception; organelle organization and biogenesis; response to stimulus; cilium biogenesis
Disease: Bardet-biedl Syndrome 9
Research Articles on BBS9
1. Robust associations with nonsyndromic sagittal craniosynostosis were found in a 120-kb region downstream of BMP2 flanked by rs1884302 and rs6140226 and within a 167-kb region of BBS9 between rs10262453 and rs17724206.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
