optic atrophy 1 (autosomal dominant), ELISA Kit

Mouse Dynamin-like 120 kDa protein; mitochondrial (OPA1) ELISA kit; FLJ12460; KIAA0567; MGM1; NPG; NTG; largeG; mitochondrial dynamin-like GTPase; optic atrophy 1; optic atrophy 1 (autosomal dominant)

For Research Use Only. Not for use in diagnostic procedures.

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of OPA1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9325925 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the optic atrophy 1 (autosomal dominant) (OPA1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing OPA1. The ELISA analytical biochemical technique of the MBS9325925 kit is based on OPA1 antibody-OPA1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect OPA1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, OPA1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of OPA1 (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

111,339 Da

Dynamin-like 120 kDa protein, mitochondrial

LargeG  [Similar Products]

OPA1_MOUSE

OPA1: a dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. Defects in OPA1 are the cause of optic atrophy 1 and deafness. Eight splice-variant isoforms have been described.

Protein type: Mitochondrial; Apoptosis; Membrane protein, integral; Hydrolase; EC 3.6.5.5

Cellular Component: nucleoplasm; mitochondrial crista; mitochondrial outer membrane; membrane; mitochondrion; cytoplasm; mitochondrial inner membrane; dendrite; integral to membrane; mitochondrial intermembrane space

Molecular Function: GTPase activity; protein binding; GTP binding; hydrolase activity; nucleotide binding

Biological Process: inner mitochondrial membrane organization and biogenesis; positive regulation of neuron maturation; mitochondrion organization and biogenesis; mitochondrial genome maintenance; visual perception; mitochondrial fusion; apoptosis; response to stimulus; neural tube closure

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