G protein-coupled receptor 143, ELISA Kit

Mouse G-protein coupled receptor 143 (GPR143) ELISA kit; OA1; ; G protein-coupled receptor 143

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of GPR143 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9340142 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the G protein-coupled receptor 143 (GPR143) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GPR143. The ELISA analytical biochemical technique of the MBS9340142 kit is based on GPR143 antibody-GPR143 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GPR143 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GPR143. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

44,564 Da

G protein-coupled receptor 143

G-protein coupled receptor 143; MOA1; ocular albinism type 1 protein homolog; homolog of human ocular albinism 1 (Nettleship-Falls)

G-protein coupled receptor 143

Oa1  [Similar Products]

GP143_MOUSE

GPR143: Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. Defects in GPR143 are the cause of albinism ocular type 1 (OA1); also known as Nettleship-Falls type ocular albinism. Form of albinism affecting only the eye. Pigment of the hair and skin is normal or only slightly diluted. Eyes may be severely affected with photophobia and reduced visual acuity. Nystagmus or strabismus are often associated. The irides and fundus are depigmented. Defects in GPR143 are the cause of Nystagmus congenital X-linked type 6 (NYS6). It is a condition defined as conjugated, spontaneous and involuntary ocular oscillations that appear at birth or during the first three months of life. Other associated features may include mildly decreased visual acuity, strabismus, astigmatism, and occasionally head nodding. Belongs to the G-protein coupled receptor OA family.

Protein type: Membrane protein, multi-pass; GPCR, OA family; Membrane protein, integral; Receptor, GPCR

Cellular Component: Golgi apparatus; membrane; lysosome; cell; lysosomal membrane; melanosome membrane; apical plasma membrane; plasma membrane; integral to membrane; melanosome

Molecular Function: G-protein coupled receptor activity; signal transducer activity; dopamine binding

Biological Process: synaptic transmission; G-protein coupled receptor protein signaling pathway; phosphoinositide-mediated signaling; melanosome organization and biogenesis; neuropeptide signaling pathway; melanosome localization; regulation of calcium-mediated signaling; signal transduction; melanosome transport

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