G-protein coupled receptor 143 (Gpr143), Recombinant Protein

Recombinant G-protein coupled receptor 143 (Gpr143); G-protein coupled receptor 143; MOA1 Ocular albinism type 1 protein homolog

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: X; NC_000086.7 (152781921..152808646). Location: X F2-F3; X 68.46 cM

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of Gpr143 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

44,564 Da[Similar Products]

G protein-coupled receptor 143

G-protein coupled receptor 143; MOA1; ocular albinism type 1 protein homolog; homolog of human ocular albinism 1 (Nettleship-Falls)

G-protein coupled receptor 143

Oa1  [Similar Products]

GP143_MOUSE

GPR143: Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. Defects in GPR143 are the cause of albinism ocular type 1 (OA1); also known as Nettleship-Falls type ocular albinism. Form of albinism affecting only the eye. Pigment of the hair and skin is normal or only slightly diluted. Eyes may be severely affected with photophobia and reduced visual acuity. Nystagmus or strabismus are often associated. The irides and fundus are depigmented. Defects in GPR143 are the cause of Nystagmus congenital X-linked type 6 (NYS6). It is a condition defined as conjugated, spontaneous and involuntary ocular oscillations that appear at birth or during the first three months of life. Other associated features may include mildly decreased visual acuity, strabismus, astigmatism, and occasionally head nodding. Belongs to the G-protein coupled receptor OA family.

Protein type: GPCR, OA family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: Golgi apparatus; membrane; cell; lysosome; lysosomal membrane; melanosome membrane; apical plasma membrane; melanosome; integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; signal transducer activity; dopamine binding

Biological Process: G-protein coupled receptor protein signaling pathway; synaptic transmission; phosphoinositide-mediated signaling; neuropeptide signaling pathway; melanosome organization and biogenesis; melanosome localization; regulation of calcium-mediated signaling; signal transduction; melanosome transport

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