Full Product Name
ADH1C (Alcohol Dehydrogenase 1C, Alcohol Dehydrogenase Subunit gamma, ADH3)
Product Synonym Names
Anti -ADH1C (Alcohol Dehydrogenase 1C, Alcohol Dehydrogenase Subunit gamma, ADH3)
Product Gene Name
anti-ADH1C antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
MSTAGKVIKC KAAVLWELKK PFSIEEVEVA PPKAHEVRIK MVAAGICRSD EHVVSGNLVT PLPVILGHEA AGIVESVGEG VTTVKPGDKV IPLFTPQCGK CRICKNPESN YCLKNDLGNP RGTLQDGTRR FTCSGKPIHH FVGVSTFSQY TVVDENAVAK IDAASPLEKV CLIGCGFSTG YGSAVKVAKV TPGSTCAVFG LGGVGLSVVM GCKAAGAARI IAVDINKDKF AKAKELGATE CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPDSQ NLSINPMLLL TGRTWKGAIF GGFKSKESVP KLVADFMAKK FSLDALITNI LPFEKINEGF DLLRSGKSIR TVLTF
Chromosome Location
Chromosome: 4; NC_000004.11 (100257649..100273917, complement). Location: 4q23
3D Structure
ModBase 3D Structure for P00326
Species Reactivity
Human, Mouse
Specificity
Recognizes human ADH1C. Species Crossreactivity: mouse.
Purity/Purification
Serum
Serum
Form/Format
Supplied as a liquid.
Immunogen
Full length human ADH1C, aa1-375 (NP_000660.1).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-ADH1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ADH1C antibody
Antibodies; Abs to Enzymes, Dehydrogenase
Applications Tested/Suitable for anti-ADH1C antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-ADH1C antibody
Suitable for use in Western Blot and Immunoprecipitation.
NCBI/Uniprot data below describe general gene information for ADH1C. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000660.1
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NCBI GenBank Nucleotide #
NM_000669.3
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UniProt Primary Accession #
P00326
[Other Products]
UniProt Secondary Accession #
Q4PJ18; Q5WRV0; Q6LBW4; Q6NWV0; Q6NZA7[Other Products]
UniProt Related Accession #
P00326[Other Products]
Molecular Weight
39,868 Da[Similar Products]
NCBI Official Full Name
alcohol dehydrogenase 1C
NCBI Official Synonym Full Names
alcohol dehydrogenase 1C (class I), gamma polypeptide
NCBI Official Symbol
ADH1C [Similar Products]
NCBI Official Synonym Symbols
ADH3
[Similar Products]
NCBI Protein Information
alcohol dehydrogenase 1C; ADH, gamma subunit; aldehyde reductase; alcohol dehydrogenase subunit gamma; alcohol dehydrogenase 3 (class I), gamma polypeptide
UniProt Protein Name
Alcohol dehydrogenase 1C
UniProt Synonym Protein Names
Alcohol dehydrogenase subunit gamma
Protein Family
Alcohol dehydrogenase
UniProt Gene Name
ADH1C [Similar Products]
UniProt Synonym Gene Names
ADH3 [Similar Products]
UniProt Entry Name
ADH1G_HUMAN
NCBI Summary for ADH1C
This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]
UniProt Comments for ADH1C
Catalytic activity: An alcohol + NAD+ = an aldehyde or ketone + NADH.
Cofactor: Binds 2 zinc ions per subunit.
Subunit structure: Dimer of identical or non-identical chains of three types; alpha, beta and gamma.
Subcellular location: Cytoplasm.
Polymorphism: Two main alleles are known, ADH3*1 or gamma-1 has Arg-272/Ile-350 while ADH3*2 or gamma-2 has Gln-272/Val-350. ADH3*1 is associated with a fast rate of ethanol oxidation and ADH3*2 with a slow rate.
Miscellaneous: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.
Sequence similarities: Belongs to the zinc-containing alcohol dehydrogenase family.
Caution: The reference genome assembly, GRCh37, describes a non-functional copy of that gene with a stop codon at position 78. However, this premature stop codon is not present in available mRNAs.
Research Articles on ADH1C
1. additional support for the association of SNP rs1614972 in ADH1C with alcohol dependence
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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