Full Product Name
Epo-R Antibody
Product Synonym Names
EPO-R; EPOR; Erythropoietin receptor precursor
Product Gene Name
anti-Epo-R antibody
[Similar Products]
Product Synonym Gene Name
EPOR[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P19235
Species Reactivity
Human, Mouse, Rat
Specificity
Epo-R Antibody detects endogenous levels of total Epo-R protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human Epo-R.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-Epo-R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-Epo-R antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-Epo-R antibody
WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:5000
Immunofluorescence (IF) of anti-Epo-R antibody
Immunofluorescence analysis of HeLa cells, using Epo-R Antibody. The picture on the right is blocked with the synthesized peptide.
Western Blot (WB) of anti-Epo-R antibody
Western blot analysis of lysates from COS7 cells, treated with EPO 20U/ml 15', using Epo-R Antibody. The lane on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for Epo-R. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000112.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000121.3
[Other Products]
UniProt Primary Accession #
P19235
[Other Products]
UniProt Secondary Accession #
Q15443; Q2M205; B2RCG4[Other Products]
UniProt Related Accession #
P19235[Other Products]
NCBI Official Full Name
erythropoietin receptor
NCBI Official Synonym Full Names
erythropoietin receptor
NCBI Official Symbol
EPOR [Similar Products]
NCBI Official Synonym Symbols
EPO-R
[Similar Products]
NCBI Protein Information
erythropoietin receptor
UniProt Protein Name
Erythropoietin receptor
UniProt Gene Name
EPOR [Similar Products]
UniProt Synonym Gene Names
EPO-R [Similar Products]
NCBI Summary for Epo-R
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Comments for Epo-R
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
Research Articles on Epo-R
1. High EPOR expression is associated with monoclonal gammopathy of undetermined significance and multiple myeloma.
Precautions
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Disclaimer
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