Full Product Name
Epo-R (Ab-426) Antibody
Product Synonym Names
Erythropoietin receptor; EPO-R
Product Gene Name
anti-Epo-R antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P19235
Species Reactivity
Human, Mouse, Rat
Specificity
Epo-R (Ab-426) Antibody detects endogenous levels of total Epo-R protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from Internal of human Epo-R.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-Epo-R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-Epo-R antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-Epo-R antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-Epo-R antibody
WB: 1:500~1:1000
ELISA: 1:20000
Western Blot (WB) of anti-Epo-R antibody
Western blot analysis of extracts from JurKat cells, using Epo-R (Ab-426) Antibody.
NCBI/Uniprot data below describe general gene information for Epo-R. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000112.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000121.3
[Other Products]
UniProt Primary Accession #
P19235
[Other Products]
UniProt Secondary Accession #
Q15443; Q2M205; B2RCG4[Other Products]
UniProt Related Accession #
P19235[Other Products]
Molecular Weight
35,809 Da
NCBI Official Full Name
erythropoietin receptor
NCBI Official Synonym Full Names
erythropoietin receptor
NCBI Official Symbol
EPOR [Similar Products]
NCBI Official Synonym Symbols
EPO-R
[Similar Products]
NCBI Protein Information
erythropoietin receptor
UniProt Protein Name
Erythropoietin receptor
UniProt Gene Name
EPOR [Similar Products]
UniProt Synonym Gene Names
EPO-R [Similar Products]
NCBI Summary for Epo-R
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Comments for Epo-R
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
Product References and Citations for anti-Epo-R antibody
Winkelmann J.C., Blood 76:24-30(1990) [PubMed: 2163695]. Jones S.S., Blood 76:31-35(1990) [PubMed: 2163696]. Noguchi C.T., Blood 78:2548-2556(1991) [PubMed: 1668606]. Jones S.S., Blood 76:31-35(1990) [PubMed: 2163696]. Noguchi C.T., Blood 78:2548-2556(1991) [PubMed: 1668606].
Research Articles on Epo-R
1. Study reports for the first evidence that EPOR modulates breast cancer cell morphology changes upon tamoxifen treatment, which result in increased formation of cell protrusions and subsequent cell death and, proposes sustained AKT phosphorylation in EPOR-overexpressing cells as a mechanism that can lead to EPOR-induced tamoxifen resistance.
Precautions
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