Full Product Name
NYX Polyclonal Antibody
Product Gene Name
anti-NYX antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9GZU5
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purification
Immunogen
Recombinant Protein
Immunogen
Recombinant protein of human NYX
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Notes
Small volumes of anti-NYX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NYX antibody
The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB.
Applications Tested/Suitable for anti-NYX antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-NYX antibody
WB 1:500 - 1:2000
IHC 1:50 - 1:200
Western Blot (WB) of anti-NYX antibody
Western blot analysis of extracts of 293T cells, using NYX antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
Immunohistochemistry (IHC) of anti-NYX antibody
Immunohistochemistry of paraffin-embedded human prostate using NYX antibody at dilution of 1:100 (40x lens).
Immunohistochemistry (IHC) of anti-NYX antibody
Immunohistochemistry of paraffin-embedded mouse lung using NYX antibody at dilution of 1:100 (40x lens).
NCBI/Uniprot data below describe general gene information for NYX. It may not necessarily be applicable to this product.
NCBI Accession #
NP_072089.1
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NCBI GenBank Nucleotide #
NM_022567.2
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UniProt Primary Accession #
Q9GZU5
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UniProt Secondary Accession #
Q2M1S4; Q5H983; Q9H4J0; D3DWC0[Other Products]
UniProt Related Accession #
Q9GZU5[Other Products]
NCBI Official Full Name
nyctalopin
NCBI Official Synonym Full Names
nyctalopin
NCBI Official Symbol
NYX [Similar Products]
NCBI Official Synonym Symbols
CLRP; NBM1; CSNB1; CSNB4; CSNB1A
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NCBI Protein Information
nyctalopin
UniProt Protein Name
Nyctalopin
Protein Family
Nyctalopin
UniProt Gene Name
NYX [Similar Products]
UniProt Synonym Gene Names
CLRP [Similar Products]
UniProt Entry Name
NYX_HUMAN
NCBI Summary for NYX
The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB. [provided by RefSeq, Oct 2008]
UniProt Comments for NYX
NYX: Defects in NYX are the cause of congenital stationary night blindness type 1A (CSNB1A); also called X- linked congenital stationary night blindness (XLCSNB). Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. CSNB1A is characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: Xp11.4
Cellular Component: proteinaceous extracellular matrix; intracellular
Biological Process: visual perception; response to stimulus
Disease: Night Blindness, Congenital Stationary, Type 1a
Research Articles on NYX
1. Loss of ERG amplitude and apparent ON-pathway dysfunction at high temporal frequencies distinguish this patient with a Trp237Ter NYX mutation from those with other previously reported NYX mutations.
Precautions
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Disclaimer
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