Product Name
EMD, cDNA Clone
Full Product Name
EMD cDNA Clone
Product Gene Name
EMD cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggacaact acgcagatct ttcggatacc gagctgacca ccttgctgcg ccggtacaac atcccgcacg ggcctgtagt aggatcaact cgtaggcttt acgagaagaa gatcttcgag tacgagaccc agaggcggcg gctctcgccc cccagctcgt ccgccgcctc ctcttatagc ttctctgact tgaattcgac tagaggggat gcagatatgt atgatcttcc caagaaagag gacgctttac tctaccagag caagggctac aatgacgact actatgaaga gagctacttc accaccagga cttatgggga gcccgagtct gccggcccgt ccagggctgt ccgccagtca gtgacttcat tcccagatgc tgacgctttc catcaccagg tgcatgatga cgatcttttg tcttcttctg aagaggagtg caaggatagg gaacgcccca tgtacggccg ggacagtgcc taccagagca tcacgcacta ccgccctgtt tcagcctcca ggagctccct ggacctgtcc tattatccta cttcctcctc cacctctttt atgtcctcct catcatcttc ctcttcatgg ctcacccgcc gtgccatccg gcctgaaaac cgtgctcctg gggctgggct gggccaggat cgccaggtcc cgctctgggg ccagctgctg cttttcctgg tctttgtgat cgtcctcttc ttcatttacc acttcatgca ggctgaagaa ggcaacccct tctag
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of EMD cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for EMD. It may not necessarily be applicable to this product.
NCBI Accession #
BC000738
[Other Products]
UniProt Secondary Accession #
Q6FI02[Other Products]
UniProt Related Accession #
P50402[Other Products]
Molecular Weight
28,994 Da
NCBI Official Full Name
Homo sapiens emerin, mRNA
NCBI Official Synonym Full Names
emerin
NCBI Official Symbol
EMD [Similar Products]
NCBI Official Synonym Symbols
STA; EDMD; LEMD5
[Similar Products]
NCBI Protein Information
emerin
UniProt Protein Name
Emerin
UniProt Gene Name
EMD [Similar Products]
UniProt Synonym Gene Names
EDMD; STA [Similar Products]
UniProt Entry Name
EMD_HUMAN
NCBI Summary for EMD
Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008]
UniProt Comments for EMD
emerin: a single pass membrane protein that spans the inner nuclear membrane. A serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It interacts with lamins A and C, and mediates membrane anchorage to the cytoskeleton. Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through an exportin 1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Colocalized with BAF at the central region of the assembling nuclear rim, near spindle-attachment sites. Hyper-phosphorylated on tyrosine in cells overexpressing HER2. Directly phosphorylated by Src and Abl. Phosphorylated by Src at Y59, Y74 and Y95. May function as a downstream effector and signal integrator for tyrosine kinase signaling pathways at the nuclear envelope. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene.
Protein type: Cytoskeletal; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: cell-cell adherens junction; endoplasmic reticulum; membrane; nuclear envelope; nuclear inner membrane; nuclear membrane; nuclear outer membrane
Molecular Function: actin binding; beta-tubulin binding; protein binding
Biological Process: mitotic nuclear envelope disassembly; mitotic nuclear envelope reassembly; muscle contraction; muscle development; negative regulation of fibroblast proliferation; positive regulation of protein export from nucleus
Disease: Emery-dreifuss Muscular Dystrophy 1, X-linked
Research Articles on EMD
1. X-linked Emery-Dreifuss muscular dystrophy may occur along with dilative cardiomyopathy.
Precautions
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Disclaimer
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