Product Name
CCL26, siRNA
Full Product Name
CCL26 siRNA (Human)
Product Synonym Names
SCYA26; C-C motif chemokine 26; CC chemokine IMAC; Eotaxin-3; Macrophage inflammatory protein 4-alpha; MIP-4-alpha; Small-inducible cytokine A26; Thymic stroma chemokine-1; TSC-1
Product Gene Name
CCL26 sirna
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y258
Specificity
CCL26 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
Purity/Purification
> 97%
Form/Format
Lyophilized powder
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
Components
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human CCL26 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Negative Control
siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
Other Notes
Small volumes of CCL26 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CCL26 sirna
siRNA to inhibit CCL26 expression using RNA interference
Applications Tested/Suitable for CCL26 sirna
RNA Interference (RNAi)
NCBI/Uniprot data below describe general gene information for CCL26. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006063.1
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NCBI GenBank Nucleotide #
NM_006072.4
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UniProt Primary Accession #
Q9Y258
[Other Products]
UniProt Secondary Accession #
Q52LV8; A0N0Q5[Other Products]
UniProt Related Accession #
Q9Y258[Other Products]
Molecular Weight
10,648 Da
NCBI Official Full Name
C-C motif chemokine 26
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 26
NCBI Official Symbol
CCL26 [Similar Products]
NCBI Official Synonym Symbols
IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha
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NCBI Protein Information
C-C motif chemokine 26
UniProt Protein Name
C-C motif chemokine 26
UniProt Synonym Protein Names
CC chemokine IMAC; Eotaxin-3; Macrophage inflammatory protein 4-alpha; MIP-4-alpha; Small-inducible cytokine A26; Thymic stroma chemokine-1; TSC-1
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL26 [Similar Products]
UniProt Synonym Gene Names
SCYA26; MIP-4-alpha; TSC-1 [Similar Products]
UniProt Entry Name
CCL26_HUMAN
NCBI Summary for CCL26
This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2008]
UniProt Comments for CCL26
CCL26: Chemotactic for eosinophils and basophils. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Chemokine; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: extracellular space
Molecular Function: chemokine activity
Biological Process: positive regulation of actin filament polymerization; cell-cell signaling; immune response; positive regulation of endothelial cell proliferation; signal transduction; inflammatory response; chemotaxis; positive regulation of cell migration
Research Articles on CCL26
1. The most potent inhibition of RANTES, eotaxin and eotaxin3 as well as MMP9 activity.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
