Product Name
Emerin (EMD), Blocking Peptide
Full Product Name
Emerin Peptide
Product Synonym Names
STA; EDMD; LEMD5; STA; Emerin; emerin
Product Gene Name
EMD blocking peptide
[Similar Products]
Emerin peptide (MBS152930) is used for blocking the activity of Emerin antibody (MBS150246)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P50402
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
19 amino acid peptide from near the amino terminus of human Emerin
Preparation and Storage
Store Emerin peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of EMD blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for EMD blocking peptide
Blocking (BL)
Application Notes for EMD blocking peptide
Emerin peptide is used for blocking the activity of Emerin antibody.
NCBI/Uniprot data below describe general gene information for EMD. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000108
[Other Products]
NCBI GenBank Nucleotide #
NM_000117.2
[Other Products]
UniProt Primary Accession #
P50402
[Other Products]
UniProt Secondary Accession #
Q6FI02[Other Products]
UniProt Related Accession #
P50402[Other Products]
Molecular Weight
28,994 Da
NCBI Official Full Name
emerin
NCBI Official Synonym Full Names
emerin
NCBI Official Symbol
EMD [Similar Products]
NCBI Official Synonym Symbols
STA; EDMD; LEMD5
[Similar Products]
NCBI Protein Information
emerin; LEM domain containing 5
UniProt Protein Name
Emerin
UniProt Gene Name
EMD [Similar Products]
UniProt Synonym Gene Names
EDMD; STA [Similar Products]
UniProt Entry Name
EMD_HUMAN
NCBI Summary for EMD
Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008]
UniProt Comments for EMD
emerin: a single pass membrane protein that spans the inner nuclear membrane. A serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It interacts with lamins A and C, and mediates membrane anchorage to the cytoskeleton. Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through an exportin 1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Colocalized with BAF at the central region of the assembling nuclear rim, near spindle-attachment sites. Hyper-phosphorylated on tyrosine in cells overexpressing HER2. Directly phosphorylated by Src and Abl. Phosphorylated by Src at Y59, Y74 and Y95. May function as a downstream effector and signal integrator for tyrosine kinase signaling pathways at the nuclear envelope. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene.
Protein type: Membrane protein, integral; Cytoskeletal
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: nuclear outer membrane; microtubule; nuclear membrane; membrane; endoplasmic reticulum; integral to membrane; nuclear inner membrane; nuclear envelope
Molecular Function: protein binding; beta-tubulin binding; actin binding
Biological Process: positive regulation of protein export from nucleus; muscle development; mitotic nuclear envelope reassembly; muscle contraction; negative regulation of fibroblast proliferation; mitotic nuclear envelope disassembly; mitotic cell cycle
Disease: Emery-dreifuss Muscular Dystrophy 1, X-linked
Research Articles on EMD
1. Emerin, a conserved LEM-domain protein, is among the few nuclear membrane proteins for which extensive basic knowledge--biochemistry, partners, functions, localizations, posttranslational regulation, roles in development and links to human disease
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
