Full Product Name
CUL7 Polyclonal Antibody
Product Synonym Names
KIAA0076; dJ20C7.5
Product Gene Name
anti-CUL7 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
2.4mg/mL (lot specific)
Immunogen
Recombinant protein of human CUL7
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CUL7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CUL7 antibody
The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-CUL7 antibody
Applications Tested/Suitable for anti-CUL7 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-CUL7 antibody
IHC: 1:50-1:200
Immunohistochemistry (IHC) of anti-CUL7 antibody
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CUL7 Polyclonal Antibody at dilution 1:50
Immunohistochemistry (IHC) of anti-CUL7 antibody
Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CUL7 Polyclonal Antibody at dilution 1:50
NCBI/Uniprot data below describe general gene information for CUL7. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001161842.1
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NCBI GenBank Nucleotide #
NM_001168370.1
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UniProt Secondary Accession #
Q5T654; B4DYZ0; F5H0L1[Other Products]
UniProt Related Accession #
Q14999[Other Products]
Molecular Weight
199,750 Da
NCBI Official Full Name
cullin-7 isoform 1
NCBI Official Synonym Full Names
cullin 7
NCBI Official Symbol
CUL7 [Similar Products]
NCBI Official Synonym Symbols
3M1; KIAA0076; dJ20C7.5
[Similar Products]
NCBI Protein Information
cullin-7; CUL-7
UniProt Protein Name
Cullin-7
UniProt Gene Name
CUL7 [Similar Products]
UniProt Synonym Gene Names
KIAA0076; CUL-7 [Similar Products]
UniProt Entry Name
CUL7_HUMAN
NCBI Summary for CUL7
The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
UniProt Comments for CUL7
CUL7: Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity. Defects in CUL7 are the cause of 3M syndrome type 1 (3M1). An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies. Belongs to the cullin family.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: nucleoplasm; Golgi apparatus; centrosome; anaphase-promoting complex; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: ubiquitin-dependent protein catabolic process; viral reproduction; unfolded protein response; protein ubiquitination; positive regulation of dendrite morphogenesis; microtubule cytoskeleton organization and biogenesis; proteolysis; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; cytokinesis after mitosis; regulation of mitosis; epithelial to mesenchymal transition; vasculogenesis; Golgi organization and biogenesis; placenta development
Disease: Three M Syndrome 1
Research Articles on CUL7
1. CUL7, OBSL1 and CCDC8 modulate the alternative splicing of the INSR
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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