Product Name
B lymphoid tyrosine kinase (BLK), Polyclonal Antibody
Full Product Name
Rabbit anti-human B lymphoid tyrosine kinase polyclonal Antibody
Product Synonym Names
B lymphoid tyrosine kinase; BLK; MGC10442
Product Gene Name
anti-BLK antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-329 / sc-938
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-BLK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-BLK antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for BLK. It may not necessarily be applicable to this product.
NCBI Accession #
AAH32413.1
[Other Products]
UniProt Secondary Accession #
Q16291; Q96IN1[Other Products]
UniProt Related Accession #
P51451[Other Products]
Molecular Weight
57,706 Da[Similar Products]
NCBI Official Full Name
B lymphoid tyrosine kinase
NCBI Official Synonym Full Names
BLK proto-oncogene, Src family tyrosine kinase
NCBI Official Symbol
BLK [Similar Products]
NCBI Official Synonym Symbols
MODY11
[Similar Products]
NCBI Protein Information
tyrosine-protein kinase Blk; p55-Blk; b lymphocyte kinase; B lymphoid tyrosine kinase; BLK nonreceptor tyrosine kinase
UniProt Protein Name
Tyrosine-protein kinase Blk
UniProt Synonym Protein Names
B lymphocyte kinase; p55-Blk
Protein Family
Tyrosine-protein kinase
UniProt Gene Name
BLK [Similar Products]
UniProt Entry Name
BLK_HUMAN
NCBI Summary for BLK
This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]
UniProt Comments for BLK
BLK: a nonreceptor tyrosine kinase of the Src family. Expressed predominantly in B lymphocytes
Protein type: Protein kinase, TK; Kinase, protein; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; Src family
Chromosomal Location of Human Ortholog: 8p23-p22
Cellular Component: extrinsic to internal side of plasma membrane
Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding
Biological Process: B cell receptor signaling pathway; positive regulation of insulin secretion; innate immune response; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation; T cell differentiation
Disease: Maturity-onset Diabetes Of The Young, Type 11
Research Articles on BLK
1. results demonstrated that both lupus-associated functional variants contribute to the autoimmune disease association by modulating transcription of BLK in B cells and thus potentially altering immune responses
Precautions
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Disclaimer
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