HAMP / Hepcidin, Monoclonal Antibody

Anti-HAMP / Hepcidin Antibody (clone 1F9) IHC-plus; HAMP; Hepcidin antimicrobial peptide; LEAP-1; LEAP1; HEPC; Hepcidin; HFE2B; PLTR; Putative liver tumor regressor; Human HAMP; Hepcidin

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1,k

1F9

Mouse

Protein A Purified

PBS, pH 7.2

0.5 mg/ml (lot specific)

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

Small volumes of anti-HAMP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Hepcidin, an human antimicrobial peptide, contains a leader sequence, a proteolysis site and a C-terminal 25 amino acid active peptide. This peptide is most active against gram-positive bacteria, but also inhibits the growth of certain yeast and gram-negative bacteria. HAMP also functions as a signaling molecule involved in the maintenance of iron homeostasis. In conjugation with HFE it seems to regulate both intestinal iron absorption and iron storage in macrophages.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

ELISA, IHC-P (5 ug/ml), WB
Usage: Tested in Western blot using the recombinant protein immunogen as the protein source. Sandwich ELISA (Recombinant protein).

Anti-HAMP / Hepcidin antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Anti-HAMP / Hepcidin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Detection limit for recombinant GST tagged HAMP is approximately 0.03 ng/ml as a capture antibody.

9,408 Da

hepcidin antimicrobial peptide

hepcidin; putative liver tumor regressor; liver-expressed antimicrobial peptide 1

Hepcidin

HEPC; LEAP1; LEAP-1; PLTR; Hepc25; Hepc20  [Similar Products]

HEPC_HUMAN

The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014]

HAMP: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B); also known as juvenile hemochromatosis (JH). HFE2B is a disorder of iron metabolism with excess deposition of iron in the tissues, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy. Belongs to the hepcidin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: apical cortex; extracellular region

Molecular Function: hormone activity

Biological Process: cellular iron ion homeostasis; killing of cells of another organism; defense response to bacterium; immune response; defense response to fungus

Disease: Hemochromatosis, Type 2b

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