Product Name
IFN-lambda3/IL-28B (IFNL3), Recombinant Protein
Full Product Name
Recombinant Human IFN-lambda3/IL-28B Protein
Product Synonym Names
Interleukin-28B; IL-28B; Cytokine Zcyto22; Interferon Lambda-3; IFN-Lambda-3; Interferon Lambda-4; IFN-Lambda-4; Interleukin-28C; IL-28C; IL28B; IFNL3; IFNL4; IL28C; ZCYTO22; IFN-lambda 3
Product Gene Name
IFNL3 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8IZI9
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, 1mM EDTA, pH7.4.
Endotoxin
< 1.0 EU per mug as determined by the LAL method.
Preparation and Storage
Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of IFNL3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IFNL3 recombinant protein
Protein Construction: Recombinant Human IFN-lambda3 is produced by our mammalian expression system and the target gene encoding Val22-Val196 is expressed.
Background: Interleukin-28B, also known as Cytokine Zcyto22, Interferon lambda-3, Interferon lambda-4, IFNL3, IFNL4, ZCYTO22 and IL28B, is a secreted cytokine which belongs to the IL-28/IL-29 family. IL-28 has also been shown to play a role in the adaptive immune response. IL28B has immunomodulatory activity and up-regulates MHC class I antigen expression. IL28B displays potent antiviral activity and antitumor activity. In addition, IL28B is a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.
NCBI/Uniprot data below describe general gene information for IFNL3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_742151.2
[Other Products]
NCBI GenBank Nucleotide #
NP_742151.2
[Other Products]
UniProt Primary Accession #
Q8IZI9
[Other Products]
UniProt Related Accession #
Q8IZI9[Other Products]
Molecular Weight
Molecular Mass: 19.6kDa
Actual Protein Molecular Mass: 18kDa[Actual+Protein Molecular+Mass:+18kDa" title="Find similar products with Molecular Mass: 19.6kDa
Actual Protein Molecular Mass: 18kDa">Similar Products]
NCBI Official Full Name
interferon lambda-3 isoform 2
NCBI Official Synonym Full Names
interferon lambda 3
NCBI Official Symbol
IFNL3 [Similar Products]
NCBI Official Synonym Symbols
IL28B; IL28C; IL-28B; IL-28C; IFN-lambda-3; IFN-lambda-4
[Similar Products]
NCBI Protein Information
interferon lambda-3
UniProt Protein Name
Interferon lambda-3
UniProt Synonym Protein Names
Cytokine Zcyto22; Interleukin-28B; IL-28B; Interleukin-28C
Protein Family
Interferon
UniProt Gene Name
IFNL3 [Similar Products]
UniProt Synonym Gene Names
IL28B; IL28C; ZCYTO22; IFN-lambda-3; IL-28B; IL-28C [Similar Products]
UniProt Entry Name
IFNL3_HUMAN
NCBI Summary for IFNL3
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
UniProt Comments for IFNL3
IL-28B: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19q13.13
Cellular Component: extracellular space
Molecular Function: cytokine activity
Biological Process: positive regulation of immune response; negative regulation of viral genome replication; JAK-STAT cascade; defense response to virus
Disease: Hepatitis C Virus, Susceptibility To
Research Articles on IFNL3
1. We confirmed two previously reported significant associations, in the IL28B/IFNL4 and the major histocompatibility complex (MHC) regions, with spontaneous clearance in the European population. We further fine-mapped the association in the MHC to a region of about 50 kilo base pairs, down from 1 mega base pairs in the previous study.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
